Chemical Properties
clear colorless to pale yellow liquid
Uses
Diethyl 1,3-acetonedicarboxylate was used in the synthesis of novel pyrido[4,3,2-de]quinoline, isoquinolino[6,5,4,3-cde] quinoline and pyrazomycin. It was used as starting reagent in the synthesis of (±)-thienamycin, potent β-lactam antibiotic.
Pharmaceutical Applications
Azoles, are valuables five membered nitrogen heterocycles, mainly those with 1,2,3-triazoles nucleus. Since they display intriguing pharmacological properties associated with a wide spectrum of biological activities like: anticancer, antiviral, antifungal, anti-acetyl-cholinesterase, anti-inflammatory, antioxidant, antidiabetic and anti-HIV. Diethyl 1,3-acetonedicarboxylate can be used as a raw material for the synthesis of 1,2,3-triazoles.[1]
References
[1] REACTION OF SOME X-PHENYLAZIDES DERIVATIVES WITH DIETHYL 1,3-ACETONEDICARBOXYLATE. Rev. Roum. Chim., 2021, 66(5), 445–448. DOI:10.33224/rrch.2021.66.5.07
