Methylamine Hcl

Description

Methylamine Hcl is a colorless organic solid that has an odor similar to that of fish and is used as an essential part for the synthesis of a wide variety of commercial compounds such as ephedrine, theophylline, and other intermediates for a wide range of agricultural chemicals, including herbicides, fungicides, insecticides, biocides, and miticides. Methylamine Hcl is also a key ingredient in the synthesis of methamphetamine. It is very soluble in N, N-Dimethylformamide, methanol, sparingly soluble in glacial acetic acid, and very slightly soluble in chloroform.

Uses

Methylamine Hcl can be used as a reactant to synthesize Betahistine via aza-Michael reaction with 2-vinylpyridine in water. It could be used to synthesize Azatripyrrolic and azatetrapyrrolic macrocycles by reacting with pyrrole and formaldehyde via base-catalyzed Mannich reaction and Tetrahydropyridines via Aza-Diels–Alder reaction with dienes and aldehydes. In addition, it synthesizes N-methylsecondary arylamines from aryl chlorides via nickel-catalyzed amination reaction.

Production Methods

Methylamine Hcl is obtained by heating two equivalents of formaldehyde (as formalin) with ammonium chloride at about 100°. Any dimethylamine hydrochloride formed may be removed by extraction with chloroform.