PARAMETHADIONE (500 MG)

Bezeichnung:PARAMETHADIONE (500 MG)

CAS-Nr115-67-3

Englisch Name:PARAMETHADIONE (500 MG)

CBNumberCB9500518

SummenformelC7H11NO3

Molgewicht157.17

MOL-Datei115-67-3.mol

PARAMETHADIONE (500 MG) physikalisch-chemischer Eigenschaften

Schmelzpunkt	31-32 °C
Siedepunkt	281.82°C (rough estimate)
Dichte	d425 1.1180-1.1240
Brechungsindex	nD25 1.449
pka	-2.18±0.40(Predicted)
EPA chemische Informationen	Paramethadione (115-67-3)

Sicherheit

Giftige Stoffe Daten	115-67-3(Hazardous Substances Data)
Toxizität	LD50 orl-mus: 1000 mg/kg 27ZQAG -,280,72

PARAMETHADIONE (500 MG) Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Paradione,Abbott, US ,1949
Verwenden
Paramethadione is also used in minor forms of epilepsy.
Verwenden
Paramethadione acts as an antiepileptic and anticonvulsant agent.
Definition
ChEBI: Paramethadione is an oxazolidinone.
Manufacturing Process
About 143.1 grams (one mol) of 5-methyl-5-ethyloxazolidine-2,4-dione is dissolved in 300 cc of methanol containing 23 grams of sodium. To the above mixture is added 126 grams of dimethyl sulfate in 10 cc portions while the temperature is maintained at about 50°C by external cooling. The mixture is then heated briefly to boiling, cooled, diluted with about 500 cc of water and extracted with two 250 cc portions of benzene. The benzene extract is separated, washed once with sodium bicarbonate solution and once with water. The benzene is removed by evaporation on a steam bath and the residue is fractionally distilled. The material boiling at 112° to 116°C at 25 mm pressure is taken; nD25=1.4495. Upon further fractionation, a very pure specimen boils at 101°-102°C at 11 mm.
The 5-methyl-5-ethyloxazolidine-2,4-dionemay be prepared by reacting methyl ethyl ketone with sodium cyanide and with ammonium thiocyanate followed by desulfurization. This intermediate may also be prepared by condensing α-hydroxy-α-methylbutyramide with ethyl chlorocarbonate or by condensing ethyl α-hydroxy-α-methylbutyrate with urea. Another method described (Traube and Aschar, Ber., 46, 2077-1913) consists in the condensation of ethyl α-hydroxy-α-methylbutyrate with guanidine followed by hydrolysis.
Trademarks
Paradione (Abbott).
Therapeutic Function
Anticonvulsant
Sicherheitsprofil
Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic effects. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx.
Synthese
Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione (9.8.3), differs from trimethadione only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid [29].

PARAMETHADIONE (500 MG) Upstream-Materialien And Downstream Produkte

PARAMETHADIONE (500 MG) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

115-67-3, PARAMETHADIONE (500 MG) Verwandte Suche:

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