Adenosine 5'-monophosphate monohydrate

Bezeichnung:Adenosine 5'-monophosphate monohydrate

CAS-Nr18422-05-4

Englisch Name:Adenosine 5'-monophosphate monohydrate

CBNumberCB9343816

SummenformelC10H16N5O8P

Molgewicht365.24

MOL-Datei18422-05-4.mol

Adenosine 5'-monophosphate monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	183-188 °C (dec.)(lit.)
alpha	-48 º (c=2% in 2% NaOH)
FEMA	4224 \| ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE
storage temp.	-20°C
Löslichkeit	H₂O: with addition of mild alkalisoluble
Aggregatzustand	Solid
Farbe	White to Off-White
Merck	14,158
BRN	5205540
CAS Datenbank	18422-05-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	AU7480500
F	8-10-21
TSCA	Yes
HS Code	2934999090

Gefahreninformationscode (GHS)

Adenosine 5'-monophosphate monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against HSV-1 and HSV-2. It plays an important role in various biochemical pathways such as energy metabolism, gene expression and signal transduction.
Chemische Eigenschaften
White crystalline powder
Verwenden
Adenosine 5′-monophosphate (5′AMP) is suitable for use as
- a reagent in the synthesis of adenosine-5′-phosphoimidazolide
- an activator of phosphorylase b in the polymerization reaction for the synthesis of branched polysaccharides
- an inhibitor of endogenous NMN adenylyltransferase (NMNAT) activity that converts NMN to NAD⁺
Verwenden
Nutrient;Ca++ channel block
Definition
ChEBI: Adenosine 5'-monophosphate monohydrate is a purine ribonucleoside monophosphate.
Biochem/physiol Actions
Adenosine 5′-monophosphate (5′-AMP) has many uses in nature. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). AMP inhibits dephosphorylation of AMPK and promotes phosphorylation of AMPK by upstream kinases.
läuterung methode
The acid has been recrystallised from H2O (fine needles) and is freely soluble in boiling H2O. It crystallises also from H2O on addition of acetone. Alternatively purify it by chromatography on Dowex 1 (in formate form), eluting with 0.25M formic acid. It is then adsorbed onto charcoal (which had been boiled for 15minutes with M HCl, washed free of chloride and dried at 100o) and recovered by stirring three times with isoamyl alcohol/H2O (1:9 v/v). The aqueous layer from the combined extracts is evaporated to dryness under reduced pressure, and the product is crystallised twice from hot H2O. [Morrison & Doherty Biochem J 79 433 1961]. It has max 259nm ( 15,400) in H2O at pH 7.0. [Alberty et al. J Biol Chem 193 425 1951, Martell & Schwarzenbach Helv Chim Acta 39 653 1956]. The acridinium salt has m 208o [Baddiley & Todd J Chem Soc 648 1947, Pettit Synthetic Nucleotides, van Nostrand-Reinhold, NY, Vol 1 252 1972, NMR: Sarma et al. J Am Chem Soc 96 7337 1974, Norton et al. J Am Chem Soc 98 1007 1976, IR of diNa salt: Miles Biochem Biophys Acta 27 324 1958]. [Beilstein 26 III/IV 3615.]

Adenosine 5'-monophosphate monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

18422-05-4, Adenosine 5'-monophosphate monohydrate Verwandte Suche:

Send Inquriy