Adenosin-3',5'-phosphatmonohydrat

Bezeichnung:Adenosin-3',5'-phosphatmonohydrat

CAS-Nr60-92-4

Englisch Name:Cyclic AMP

CBNumberCB8747868

SummenformelC10H12N5O6P

Molgewicht329.21

MOL-Datei60-92-4.mol

Synonyma

Adenosin-3',5'-phosphatmonohydrat

Adenosin-3',5'-phosphatmonohydrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	260 °C (dec.)(lit.)
alpha	-53.7 º (c=0.7,water)
Siedepunkt	56.12°C
Dichte	2.47±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	H₂O: 10 mg/mL pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20×
Aggregatzustand	powder
pka	1.00±0.60(Predicted)
Farbe	white
Wasserlöslichkeit	50 mg/mL
Merck	14,2708
BRN	52645
Stabilität	Hygroscopic
NIST chemische Informationen	Adenosine 3',5'-cyclic monophosphate(60-92-4)
EPA chemische Informationen	Adenosine, cyclic 3',5'-(hydrogen phosphate) (60-92-4)

Sicherheit

Kennzeichnung gefährlicher	C,Xi
R-Sätze:	34-36/37/38
S-Sätze:	22-24/25-45-36/37/39-26-36
WGK Germany	3
RTECS-Nr.	AU7357600
F	10-21
TSCA	Yes
HS Code	29349990
Toxizität	oms-hmn:oth 100 mmol/L JIDEAE 65,52,75

Gefahreninformationscode (GHS)

Cyclic AMP Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White crystalline or Pale yellow powder; odorless. Slightly soluble in water, almost insoluble in ethanol or ether.
Verwenden
cAMP is used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells when treated with adenosine-3': 5'-cyclic monophosphate. In the presence of adenosine 3':5'-cyclic monophosphate, protein kinase I dissociated into two subunits: a subunit binding adenosine 3':5'-cyclic monophosphate, and a catalytic subunit. Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3',5'-cyclic monophosphate.
Definition
ChEBI: Cyclic AMP is a 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an adenyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic AMP(1-).
Allgemeine Beschreibung
Cyclic AMP is a second messenger molecule comprised of an adenine ribonucleotide bearing a phosphate group bound to the oxygen molecules at the 3' and 5' positions of the sugar moiety. Cyclic AMP, which is synthesized from ATP by the intracellular enzyme adenylate cyclase, modulates the activity of several hormone-dependent signal transduction pathways.
Biochem/physiol Actions
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.
Sicherheitsprofil
Human mutation data reported.When heated to decomposition it emits toxic fumes ofPOx and NOx.
Synthese
Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell.[1] Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs)-protein-coupled receptors. Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline.
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase.

Cyclic AMP Upstream-Materialien And Downstream Produkte

Adenosin-3',5'-phosphatmonohydrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

60-92-4, Cyclic AMP Verwandte Suche:

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