Adenosin-5'-(trihydrogen-diphosphat), 2'-(Dihydrogen-phosphat), 5'-5'-Ester mit 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium-hydroxid, inneres Salz, Mononatriumsalz

Bezeichnung:Adenosin-5'-(trihydrogen-diphosphat), 2'-(Dihydrogen-phosphat), 5'-5'-Ester mit 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium-hydroxid, inneres Salz, Mononatriumsalz

CAS-Nr1184-16-3

Englisch Name:NADP sodium salt

CBNumberCB6355458

SummenformelC21H29N7NaO17P3

Molgewicht767.41

MOL-Datei1184-16-3.mol

Synonyma

Adenosin-5'-(trihydrogen-diphosphat), 2'-(Dihydrogen-phosphat), 5'-5'-Ester mit 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium-hydroxid, inneres Salz, Mononatriumsalz

Adenosin-5'-(trihydrogen-diphosphat), 2'-(Dihydrogen-phosphat), 5'-5'-Ester mit 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium-hydroxid, inneres Salz, Mononatriumsalz physikalisch-chemischer Eigenschaften

Schmelzpunkt	175-178 °C (dec.)(lit.)
storage temp.	-20°C
Löslichkeit	H₂O: 50 mg/mL
Aggregatzustand	powder
Farbe	off-white to yellow
PH	2.0-4.0
Wasserlöslichkeit	Soluble in water.
Merck	14,6344
BRN	4779954
InChIKey	JNUMDLCHLVUHFS-QYZPTAICSA-M
SMILES	[Na+].[H]O[H].NC(=O)c1ccc[n+](c1)C2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@@H]([C@@H]3O)P(O)(O)=O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36-36/37/38
S-Sätze:	22-24/25-37/39-36-26
WGK Germany	3
RTECS-Nr.	UU3440000
HS Code	29349990
Speicherklasse	11 - Combustible Solids

Gefahreninformationscode (GHS)

NADP sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
NADP sodium salt is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').It is used by all forms of cellular life.
Chemische Eigenschaften
White to slightly yellowish powder
Verwenden
β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions.
β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate is a substrate NADP which plays a role in a variety of metabolic processes.
Verwenden
NADP sodium salt acts as an electron acceptor used by cells. It is also useful in vitro to study NADP. Furthermore, it is used in a wide range of enzyme catalyzed oxidation reduction reactions. The combination of NADP+/NADPH is employed in a variety of antioxidation mechanisms, which protect against reactive oxidation species accumulation.
Biosynthese
A process for preparing NADP sodium salt comprising performing phosphorylation using a polyphosphoric acid or a salt thereof and nicotinamide adenine dinucleotide (NAD+) as substrates in the presence of a polyphosphate-dependent NAD+ kinase from a Mycobacterium, wherein the reaction solution contains 0.1-15% by weight of the polyphosphoric acid or a salt thereof, and 5-150 mM of a divalent metal ion.
Biologische Funktion
NADP sodium salt is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. It plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Biochem/physiol Actions
Electron acceptor
Mechanism of action
NADP sodium salt exerts its effect by competitively inhibiting nucleotide metabolism through the suppression of enzymes like nucleoside diphosphate kinase (NDPK) and adenosine kinase (ADK). Additionally, it serves as a substrate for enzymes like DNA polymerases and RNA polymerases, enabling the integration of NADP monosodium salt into nucleic acids during replication and transcription.
Synthese
Pyridine nucleotide triphosphate, coenzyme II (NADP sodium salt) can be obtained from NADP+ by accepting the gamma-phosphate group of ATP catalyzed by a kinase.

Adenosin-5'-(trihydrogen-diphosphat), 2'-(Dihydrogen-phosphat), 5'-5'-Ester mit 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium-hydroxid, inneres Salz, Mononatriumsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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