Clinofibrate

Clinofibrate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White Solid

• Originator

  Lipocrin,Sumitomo,Japan,1981

• Verwenden

  Clinofibrate is an antilipemic, used as an anti-atherosclerosis agent.

• Definition

  ChEBI: Clinofibrate is an organic molecular entity.

• Manufacturing Process

  Into a mixture of 6.0 g of a bishydroxyphenyl derivative, and 44.0 g of methyl ethyl ketone was added 16.2 g of crushed potassium hydroxide or sodium hydroxide. Chloroform was added dropwise into the above mixture with stirring at 20°C to 80°C, and the resultant mixture was heated for 20 hours under reflux to complete the reaction. Thereafter the reaction mixture was concentrated to give a residue. Into the residue was added water. After cooling, the resultant mixture was treated with activated charcoal and acidified by diluted hydrochloric acid or sulfuric acid to give an oily substance. The oily substance was extracted by ether and the ether solution was contacted with aqueous diluted Na2CO3 solution. The separated aqueous layer was washed with ether, acidified and again extracted with ether. The obtained ester layer was dried over anhydrous sodium sulfate and concentrated to give 1.0 g of a crude product which was purified by recrystallization or chromatography, to give crystals MP 143°C to 146°C (decomp.)

• Therapeutic Function

  Antihyperlipoproteinemic

Clinofibrate Upstream-Materialien And Downstream Produkte

Clinofibrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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