3,4-Diaminobenzolsulfonsure

Bezeichnung:3,4-Diaminobenzolsulfonsure

CAS-Nr7474-78-4

Englisch Name:3,4-Diaminobenzenesulfonic acid

CBNumberCB9312890

SummenformelC6H8N2O3S

Molgewicht188.2

MOL-Datei7474-78-4.mol

Synonyma

3,4-Diaminobenzolsulfonsure

3,4-Diaminobenzolsulfonsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	-12 °C
Siedepunkt	178-179 °C3 mm Hg(lit.)
Dichte	0.936 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.441(lit.)
Flammpunkt	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	hexane, toluene, ethanol and acetone: soluble
pka	-0.52±0.50(Predicted)
Aggregatzustand	Solid
Farbe	Dark Brown
Dielectric constant	4.5（30℃）
InChI	InChI=1S/C6H8N2O3S/c7-5-2-1-4(3-6(5)8)12(9,10)11/h1-3H,7-8H2,(H,9,10,11)
InChIKey	FKSRSWQTEJTBMI-UHFFFAOYSA-N
SMILES	C1(S(O)(=O)=O)=CC=C(N)C(N)=C1
CAS Datenbank	7474-78-4(CAS DataBase Reference)
EPA chemische Informationen	Benzenesulfonic acid, 3,4-diamino- (7474-78-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	1
RTECS-Nr.	VS1150000

Gefahreninformationscode (GHS)

3,4-Diaminobenzenesulfonic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
3,4-Diaminobenzenesulfonic Acid is a useful organic synthetic reagent and a sulfonate-aminium zwitterion.
Synthese

95-54-5

7474-78-4

The general procedure for the synthesis of 3,4-diaminobenzenesulfonic acid from o-phenylenediamine was as follows: first, the sulfonation mixture was prepared by dissolving 160 g (1.48 mol) of 1,2-diaminobenzene in 800 g (435 mL; 8.16 mol) of 95-97% sulfuric acid. Subsequently, the sulfonated mixture was divided into four portions and pumped into a continuous flow microreactor for the reaction. The microreactor consisted of a sequentially connected inlet module, five residence modules and an outlet module, each of which was maintained at a constant reaction temperature. Upon completion of the reaction, the sulfonation mixture was rapidly cooled with water at the reactor outlet to allow the sulfonation reaction products to precipitate in an ice-water bath. After filtration, the resulting white product was characterized by nuclear magnetic resonance (NMR). Based on 1H-NMR spectroscopy (400 MHz, DMSO-d6) analysis, no isomers were detected in all the products isolated in the experiments, confirming the formation of 3,4-diaminobenzenesulfonic acid and the absence of impurities. The yields of the products were influenced by the reaction temperature and residence time: 80% at 160 °C reaction temperature for 25 min, 89%, 90% and 100% at 180 °C reaction temperature for 5, 10 and 25 min, respectively.
Einzelnachweise
[1] Patent: WO2012/74822, 2012, A1. Location in patent: Page/Page column 19-20
[2] Patent: EP2457886, 2012, A1. Location in patent: Page/Page column 9
[3] Patent: EP1400507, 2004, A1. Location in patent: Page 4; 5
[4] Tetrahedron, 2008, vol. 64, # 22, p. 5410 - 5415
[5] Patent: US2012/225863, 2012, A1. Location in patent: Page/Page column 40

3,4-Diaminobenzenesulfonic acid Upstream-Materialien And Downstream Produkte

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