Poly(1-vinylpyrrolidone-co-vinyl acetate)

Bezeichnung:Poly(1-vinylpyrrolidone-co-vinyl acetate)

CAS-Nr25086-89-9

Englisch Name:Poly(1-vinylpyrrolidone-co-vinyl acetate)

CBNumberCB9295023

SummenformelC10H15NO3

Molgewicht197.23

MOL-Datei25086-89-9.mol

Poly(1-vinylpyrrolidone-co-vinyl acetate) physikalisch-chemischer Eigenschaften

Dichte	1.27 g/mL at 25 °C(lit.)
Tg	108
Brechungsindex	1.4300 to 1.4380
Flammpunkt	72 °F
Löslichkeit	Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
Aggregatzustand	powder
Farbe	White
Stabilität	Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
InChI	InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChIKey	FYUWIEKAVLOHSE-UHFFFAOYSA-N
SMILES	C(N1CCCC1=O)=C.O(C=C)C(=O)C
LogP	0.370 (est)
EPA chemische Informationen	Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)

Sicherheit

Kennzeichnung gefährlicher	Xi,F
R-Sätze:	10-36/37/38-67-36-11-22
S-Sätze:	22-24/25-36/37/39-26-16
RIDADR	UN 1987 3/PG 2
WGK Germany	1
RTECS-Nr.	AH3539000
TSCA	TSCA listed
HazardClass	3
PackingGroup	II
HS Code	29349990
Toxizität	LD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83

Gefahreninformationscode (GHS)

Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Chemische Eigenschaften
Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.
Chemische Eigenschaften
white powder
Verwenden
Poly(1-vinylpyrrolidone-co-vinyl acetate)
Verwenden
Copovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.
Vorbereitung Methode
Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.
Allgemeine Beschreibung
～1:2.4 mole ratio of VP:VA
Pharmazeutische Anwendungen
Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Sicherheitsprofil
Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.
Sicherheit(Safety)
Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.
LD₅₀ (rat, oral): >0.63 g/kg
Solubility in organics
Acetone, chloroform, methanol, THF, water
Solubility in organics
THF (above 68C)
Solubility in organics
THF, water
Lager
Copovidone is stable and should be stored in a well-closed container in a cool, dry place.
Inkompatibilitäten
Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.
Regulatory Status
Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).

Poly(1-vinylpyrrolidone-co-vinyl acetate) Upstream-Materialien And Downstream Produkte

Poly(1-vinylpyrrolidone-co-vinyl acetate) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

25086-89-9, Poly(1-vinylpyrrolidone-co-vinyl acetate) Verwandte Suche:

Send Inquriy