5-Hydroxyindole Struktur

5-Hydroxyindol

Bezeichnung:5-Hydroxyindol

CAS-Nr1953-54-4

Englisch Name:5-Hydroxyindole

CBNumberCB9151600

SummenformelC8H7NO

Molgewicht133.15

MOL-Datei1953-54-4.mol

Synonyma

5-Hydroxyindol

5-Hydroxyindol physikalisch-chemischer Eigenschaften

Schmelzpunkt	106-108 °C(lit.)
Siedepunkt	245.66°C (rough estimate)
Dichte	1.1475 (rough estimate)
Brechungsindex	1.5260 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Löslichkeit	38g/l
Aggregatzustand	Crystalline Needles or Powder
pka	9.98±0.40(Predicted)
Farbe	beige
Sensitive	Light Sensitive
BRN	112349
InChI	InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H
InChIKey	LMIQERWZRIFWNZ-UHFFFAOYSA-N
SMILES	N1C2=C(C=C(O)C=C2)C=C1
CAS Datenbank	1953-54-4(CAS DataBase Reference)
NIST chemische Informationen	Indol-5-ol(1953-54-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	NM2430000
HazardClass	IRRITANT, KEEP COLD
HS Code	29339990

Gefahreninformationscode (GHS)

5-Hydroxyindole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
beige to brown crystalline needles or powder
Verwenden
• ;Reactant for preparation of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates as antitumor agents and tubulin inhibitors1• ;Reactant for preparation of anthranilic acids2• ;Reactant for preparation of indole compounds as dopamine D2 receptor antagonists3• ;Reactant for preparation of naphthalimide- or carbazole-containing human β-adrenoceptor ligands4• ;Reactant for preparation of melanins as nature-inspired radioprotectors5• ;Reactant for preparation of 5-vinyl-3-pyridinecarbonitriles as PKCθ inhibitors6
Verwenden
5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptophan (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets.
Definition
ChEBI: 5-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group. It has a role as a human metabolite.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 5579, 1954 DOI: 10.1021/ja01651a001
The Journal of Organic Chemistry, 49, p. 4833, 1984 DOI: 10.1021/jo00199a017

5-Hydroxyindole Upstream-Materialien And Downstream Produkte

5-Hydroxyindol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1953-54-4, 5-Hydroxyindole Verwandte Suche:

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