4-Hydroxyindole Struktur

4-Hydroxyindole

Bezeichnung:4-Hydroxyindole

CAS-Nr2380-94-1

Englisch Name:4-Hydroxyindole

CBNumberCB5663260

SummenformelC8H7NO

Molgewicht133.15

MOL-Datei2380-94-1.mol

4-Hydroxyindole physikalisch-chemischer Eigenschaften

Schmelzpunkt	97-99 °C(lit.)
Siedepunkt	245.66°C (rough estimate)
Dichte	1.1475 (rough estimate)
Dampfdruck	0.019Pa at 25℃
Brechungsindex	1.5260 (estimate)
storage temp.	0-6°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	9.89±0.40(Predicted)
Farbe	Dark Yellow to Green-Grey
Wasserlöslichkeit	slightly soluble
Sensitive	Air Sensitive
BRN	114905
InChIKey	NLMQHXUGJIAKTH-UHFFFAOYSA-N
LogP	1.57 at 25℃
CAS Datenbank	2380-94-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
Hazard Note	Irritant
HazardClass	IRRITANT, KEEP COLD
HS Code	29339900

Gefahreninformationscode (GHS)

4-Hydroxyindole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Off-White Cyrstalline Solid
Verwenden
4-Hydroxyindole is a Pindolol (P468000) impurity, which is a mixed adrenergic blocker and serotonin 5HT1A-receptor antagonist.
Definition
ChEBI: 4-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. It is a member of phenols and a member of hydroxyindoles.
Application
4-Hydroxyindole as simple indoles is the important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. It effectively inhibits Abeta peptide-induced amyloid fibril formation and prevent cell death induced by the peptide in culture. It is used for the synthesis of anti-inflammatory angular pyrrolocoumarins.
synthetische
Synthesis of 4-hydroxyindole: Using resorcinol as raw material, 4-oxotetrahydrocoumarone carboxylic acid is prepared by isomerization, catalytic hydrogenation, and cyclization with ethyl bromopyruvate. It was added to methanol solution saturated with ammonia, and the reaction was heated in an autoclave to generate 4-oxotetrahydroindole. Finally, 4-hydroxyindole is obtained by dehydrogenation and isomerization.
Allgemeine Beschreibung
Glucouridination of 4-hydroxyindole by human uridine 5′-diphospho-glucuronosyltransferase has been repotrted.

4-Hydroxyindole Upstream-Materialien And Downstream Produkte

4-Hydroxyindole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2380-94-1, 4-Hydroxyindole Verwandte Suche:

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