4-Vinylpyridin

Bezeichnung:4-Vinylpyridin

CAS-Nr100-43-6

Englisch Name:4-Vinylpyridine

CBNumberCB8852582

SummenformelC7H7N

Molgewicht105.14

MOL-Datei100-43-6.mol

Synonyma

4-Vinylpyridin

4-Vinylpyridin physikalisch-chemischer Eigenschaften

Schmelzpunkt	<25 °C
Siedepunkt	62-65 °C/15 mmHg (lit.)
Dichte	0.975 g/mL at 25 °C (lit.)
Dampfdruck	2.28hPa at 25℃
Brechungsindex	n20/D 1.549(lit.)
Flammpunkt	125 °F
storage temp.	-20°C
Löslichkeit	Chloroform, Methanol (Slightly)
Aggregatzustand	Liquid
pka	pK1:5.62(+1) (25°C)
Farbe	Clear colorless to yellow-brown
Wasserlöslichkeit	29 G/L (20 ºC)
BRN	104506
Expositionsgrenzwerte	ACGIH: TWA 1 mg/m3 OSHA: TWA 2 mg/m3 NIOSH: IDLH 50 mg/m3; Ceiling 2 mg/m3
Stabilität	Stable. Incompatible with strong acids, strong oxidizing agents.
LogP	1.36 at 20℃
CAS Datenbank	100-43-6(CAS DataBase Reference)
NIST chemische Informationen	Pyridine, 4-ethenyl-(100-43-6)
EPA chemische Informationen	4-Vinylpyridine (100-43-6)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	10-25-34-42/43-23/25
S-Sätze:	23-26-36/37/39-45-28A-16
RIDADR	UN 3073 6.1/PG 2
WGK Germany	3
RTECS-Nr.	UU1045000
F	8-10
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29333990
Giftige Stoffe Daten	100-43-6(Hazardous Substances Data)

Gefahreninformationscode (GHS)

4-Vinylpyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
R25:Giftig beim Verschlucken.
R34:Verursacht Verätzungen.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R23/25:Giftig beim Einatmen und Verschlucken.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
4-vinylpyridine (4VP) is a pyridine derivative with a vinyl group in the 4-position. It is a colorless liquid, although impure samples are often brown. This compound belongs to a class of polar vinyl monomers that are important in many applications due to the ability of their polymers to form complexes of the electron-rich pyridine ring and to form polyelectrolytes through protonation or quaternization with alkyl or aryl halides. 4VP is sometimes used in biochemistry to alkylate protein cysteine residues. When compared to other alkylation agents, such as iodoacetamide, acrylamide, and N-ethylmaleimide, 4VP is less reactive, meaning the completion rate of cysteine alkylation is lower, but it also yields fewer side reactions[1].
Chemische Eigenschaften
dark brown to yellow liquid. 2.9g can be dissolved in 100g of water at 20℃, soluble in methanol, ether, benzene, acetone, and slightly soluble in ether. When exposed to light and heat, polymerization occurs, and 0.1%-0.2% hydroquinone is often added as a polymerization inhibitor during storage.
Verwenden
4-Vinylpyridine acts as a co-monomer in styrene-butadiene polymers to promote adhesion between the rubber compound and supporting fibers (or cords) in tires, belts and hoses. It serves as an intermediate for manufacturing chemicals and pharmaceuticals. Further, it is used as a reagent for the modification of cysteine. In addition to this, it is used to make poly(4-vinylpyridine) and elastomers.
synthetische
4-Vinylpyridine is synthesized by reacting 4-picoline with formaldehyde to generate 4-pyridineethanol, which is then dehydrated.
Application
4-Vinylpyridine was used as a monomer in polymer chemistry and induced nonimmunological contact urticaria and allergic contact dermatitis. No crossreactivity is observed between pyridine derivatives. It can be copolymerized with many other monomers, in particular cationic monomers, such as acrylamide, acrylates, and also with other vinyl-based monomers (e.g. styrene).?
Flammability and Explosibility
Flammable
läuterung methode
6 2 . Purify the monomer by fractional distillation under a good vacuum and in a N2 atmosphere and store it in sealed ampoules under N2, and keep it in the dark at -20o. The picrate has m 175-176o. [UV: Coleman & Fuoss J Am Chem Soc 77 5472 1955, Overberger et al. J Polymer Sci 27 381 1958, Petro & Smyth J Am Chem Soc 79 6142 1957.] It is used for alkylating SH groups in peptides [Anderson & Friedman Can J Biochem 49 1042 1971, Cawins & Friedman Anal Biochem 35 489 1970]. [Beilstein 20 II 170, 20 III/IV 2887, 20/6 V 213.]
Einzelnachweise
[1] Baskaran, D. and A. Müller. “Anionic Polymerization of Polar Vinyl Monomers.” (2012): 623-655

4-Vinylpyridine Upstream-Materialien And Downstream Produkte

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