Mephentermin

Bezeichnung:Mephentermin

CAS-Nr100-92-5

Englisch Name:Mephentermine

CBNumberCB8745455

SummenformelC11H17N

Molgewicht163.26

MOL-Datei100-92-5.mol

Synonyma

Mephentermin

Mephentermin physikalisch-chemischer Eigenschaften

Schmelzpunkt	<25 °C
Siedepunkt	bp7mm 82-83°
Dichte	d2020 0.9231
Brechungsindex	n20D 1.5110
Löslichkeit	Dichloromethane; Ethyl Acetate; Methanol; DMSO
pka	pKa (30°) 10.35
Aggregatzustand	Solid
Farbe	White
NIST chemische Informationen	Benzeneethanamine, n,«alpha»,«alpha»-trimethyl-(100-92-5)

Sicherheit

Giftige Stoffe Daten

100-92-5(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Mephentermine Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Wyamine,Wyeth,US,1947
Verwenden
Adrenergic (vasoconstrictor).
Verwenden
Mephentermine is an α-adrenergic agonist. Mephentermine is used as an antihypotensive.
Definition
ChEBI: Mephentermine is a member of amphetamines.
Manufacturing Process
0.5 g of 2-(N-methylamino)-2-methyl-1-phenyl-1-propanol was treated with 1 cc of thionyl chloride at room temperature. A vigorous reaction set in. The gummy material was stirred with a small amount of petroleum ether and allowed to stand overnight. The brown crystalline solid after washing with petroleum ether was recrystallized from a small amount of absolute alcohol with addition of charcoal followed by filtration. On dilution with several volumes of ether and refrigeration white granular crystals of 1-chloro-2-(Nmethamino)-2-methyl-1-phenyl propane hydrochloride were deposited.
250 mg of 1-chloro-2-(N-methylamino)-2-methyl-1-phenyl propane hydrochloride was dissolved in 2 cc of warm methanol and hydrogenated in the presence of 250 mg of palladium barium carbonate catalyst with provision for the absorption of the carbon-dioxide formed. When the theoretical amount of hydrogen had been taken up the mixture was filtered to remove the catalyst, concentrated to small volume and extracted with ether. After separating the ether the residue was further concentrated yielding a white crystalline solid. This solid on solution in water, strongly alkalizing, extraction with ether and removal of the ether yielded 2-(N-methylamino)-2-methyl-1- phenyl propane identified as the picrate by melting point 155°C to 156°C and mixed melting point 154.0°C to 154.5°C, with an authentic sample melting at 150°C to 153°C.
Trademarks
Wyamine Sulfate (Baxter Healthcare).
Therapeutic Function
Adrenergic (vasopressor)

Mephentermine Upstream-Materialien And Downstream Produkte

100-92-5, Mephentermine Verwandte Suche:

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