N-Methyl-N-2-propinylbenzol-methanamin

Bezeichnung:N-Methyl-N-2-propinylbenzol-methanamin

CAS-Nr555-57-7

Englisch Name:Pargyline

CBNumberCB8698159

SummenformelC11H13N

Molgewicht159.23

MOL-Datei555-57-7.mol

Synonyma

Pargylin

N-Methyl-N-2-propinylbenzol-methanamin

N-Methyl-N-2-propinylbenzol-methanamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	15-20 °C
Siedepunkt	86-88 °C4 mm Hg(lit.)
Dichte	0.944 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.522(lit.)
Flammpunkt	183 °F
storage temp.	Store at -20°C
Löslichkeit	Soluble in DMSO
Aggregatzustand	Liquid
pka	pKa 6.9 (Uncertain)
Farbe	Clear yellow
Merck	14,7038

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25-36/37/38-22
S-Sätze:	26-36/37/39-45-23
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS-Nr.	DP6475000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29214900

Gefahreninformationscode (GHS)

Pargyline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
CLEAR YELLOW LIQUID
Originator
Eutonyl, Abbott , US ,1963
Verwenden
analgesic
Definition
ChEBI: Pargyline is an aromatic amine.
Manufacturing Process
A mixture of 23.8 grams (0.2 mol) of propargyl bromide, 24.2 grams (0.2 mol) of N-methylbenzylamine and 400 ml of anhydrous ethanol in the presence of 42.4 grams (0.4 mol) of anhydrous sodium carbonate was heated at the boiling temperature and under reflux for a period of 17 hours.
The sodium carbonate was then removed by filtration and the alcohol was removed by distillation under reduced pressure. The residue was treated with 300 ml of dry ether and the resulting solution was filtered to remove sodium bromide.
The filtrate was dried and fractionally distilled under reduced pressure to obtain the desired N-methyl-N-propargylbenzylamine which boiled at 96°97°C at 11 mm pressure.
Analysis calculated for C11H13N: C = 82.97%; H = 8.23%; N = 8.80%. Found: C = 82.71%; H = 8.51%; N = 8.93%.
The hydrochloride salt of this amine was prepared by dissolving the amine in ether and adding ethereal hydrogen chloride to the ether solution. The solid hydrochloride salt which precipitated was recrystallized from an ethanol-ether mixture and was found to melt at 154° - 155°C.
Trademarks
Eutonyl (Abbott).
Therapeutic Function
Antihypertensive
Enzyminhibitor
This antihypertensive agent (FWfree-base = 159.23 g/mol; CAS 555-57-7), also known as Eutonyl, N-benzyl-N-methyl-2-propynylamine, is amechanism-based inhibitor that targets monoamine oxidase, beginning with an initial reversible interaction (Ki = 4-5 μM) and proceeding to irreversible loss of enzyme activity. Target(s): aldehyde dehydrogenase, pargyline is the precursor of the actual inhibitor; bacterial bioluminescence; and monoamine oxidase.

Pargyline Upstream-Materialien And Downstream Produkte

N-Methyl-N-2-propinylbenzol-methanamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

555-57-7, Pargyline Verwandte Suche:

Send Inquriy