BLASTICIDIN S HYDROCHLORIDE

Bezeichnung:BLASTICIDIN S HYDROCHLORIDE

CAS-Nr3513-03-9

Englisch Name:BLASTICIDIN S HYDROCHLORIDE

CBNumberCB8383972

SummenformelC17H27ClN8O5

Molgewicht458.9

MOL-Datei3513-03-9.mol

BLASTICIDIN S HYDROCHLORIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	224-225 °C (decomp)
storage temp.	−20°C
Löslichkeit	Soluble in Water (greater than 25 mg/ml)
Aggregatzustand	Liquid
Farbe	White
Wasserlöslichkeit	Soluble in water. Insoluble in organic solvents.
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	28
S-Sätze:	28-36/37-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
F	1-10
HazardClass	6.1
HS Code	29349990

Gefahreninformationscode (GHS)

BLASTICIDIN S HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4
Chemische Eigenschaften
White powder
Verwenden
Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation.
Verwenden
Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis.
Verwenden
Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.
Allgemeine Beschreibung
Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.
Lager
Store at -20°C
Einzelnachweise
1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283 2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217 3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993 4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980

BLASTICIDIN S HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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