Bopindolol

Bezeichnung:Bopindolol

CAS-Nr62658-63-3

Englisch Name:Bopindolol

CBNumberCB8294403

SummenformelC23H28N2O3

Molgewicht380.48

MOL-Datei62658-63-3.mol

Bopindolol physikalisch-chemischer Eigenschaften

Schmelzpunkt	117-120°C
Siedepunkt	557.0±50.0 °C(Predicted)
Dichte	1.143±0.06 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka	17.59±0.30(Predicted)
Aggregatzustand	Solid
Farbe	White to Pale Beige

Sicherheit

Toxizität

LD50 i.v. in mice: 17 mg/kg (Troxler, Seemann, 1977)

Bopindolol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Bopindolol is a potent, long-acting, non-selective β-adrenergic blocker related to pindolol and useful in the treatment of hypertension. Unlike many other agents of this type, it appears to have negligible effects on serum lipoproteins.
Chemische Eigenschaften
Off-White to pale Yellow Solid
Originator
sandoz (Switzerland)
Verwenden
Bopindolol is an ester prodrug of Pindolol (P468000). Bopindolol is a long acting β-adrenoceptor blocking agent. Bopindolol displays antispasmogenic activity mediated by α1-adrenoceptors and 5-HT2 receptors.
Definition
ChEBI: 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate is a methylindole that is 2-methyl-1H-indol-4-ol in which the hydrogen of the hydroxy group is replaced by a 2-(benzoyloxy)-3-(tert-butylamino)propyl group. It is a methylindole, a secondary amino compound, an aromatic ether and a benzoate ester.
Manufacturing Process
4-(2-Benzoyloxy-3-t-butylaminopropoxy)-2-methyl-indole:
26 g of benzoic acid are dissolved, while heating, in 50 ml of hexamethylphosphoric acid triamide and 3.5 g of 1-t-butylamino-3-(2-methylindole- 4-yloxy)-2-propanol are added. After cooling, 3.0 g of benzoic acid anhydride are added and stirred for 20 hours at room temperature. The resulting clear, yellow solution is poured onto ice 0.5 liters of ether are added and stirred for 2 hours. After making the liquid alkaline with concentrated ammonia, the ether phase is separated, shaken out with tartaric acid, made alkaline with caustic soda solution while cooling with ice and extracted with methylene chloride. After evaporating the solvent, the residue is crystallized with 1 mol of fumaric acid from methanol and acetone.
Trademarks
SANDONORM
Therapeutic Function
Beta-adrenergic blocker

Bopindolol Upstream-Materialien And Downstream Produkte

Bopindolol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

62658-63-3, Bopindolol Verwandte Suche:

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