Dobutamine hydrochloride

Bezeichnung:Dobutamine hydrochloride

CAS-Nr49745-95-1

Englisch Name:Dobutamine hydrochloride

CBNumberCB8274063

SummenformelC18H24ClNO3

Molgewicht337.84

MOL-Datei49745-95-1.mol

Synonyma

4-[2-[[3-(p-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]brenzcatechinhydrochlorid

Dobutamine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	184-186 C
storage temp.	2-8°C
Löslichkeit	Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent).
Aggregatzustand	Solid
pka	9.45(at 25℃)
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water or ethanol with warming. Also soluble in methanol
maximale Wellenlänge (λmax)	281nm(MeOH)(lit.)
Merck	14,3395
Stabilität	Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light.
InChI	InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
InChIKey	BQKADKWNRWCIJL-UHFFFAOYSA-N
SMILES	C1(O)=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl
CAS Datenbank	49745-95-1(CAS DataBase Reference)
EPA chemische Informationen	1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-63-36/37/38-R63-R62-R11-R21-R20
S-Sätze:	22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22
WGK Germany	3
HS Code	29222990
Toxizität	LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle)

Gefahreninformationscode (GHS)

Dobutamine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.
Chemische Eigenschaften
Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.
Verwenden
Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.
Verwenden
Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.
Definition
ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure.
Trademarks
Dobutrex (Lilly）.
Biologische Aktivität
β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.
Biochem/physiol Actions
Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.
Pharmakokinetik
Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.
Veterinary Drugs and Treatments
Dobutamine is used as a rapid-acting injectable positive inotropic agent for short-term treatment of heart failure. It is also useful in shock patients when fluid therapy alone has not restored acceptable arterial blood pressure, cardiac output, or tissue perfusion.
Lager
Desiccate at RT

Dobutamine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

49745-95-1, Dobutamine hydrochloride Verwandte Suche:

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