Lobelinhydrochlorid

Bezeichnung:Lobelinhydrochlorid

CAS-Nr134-63-4

Englisch Name:alpha-Lobeline hydrochloride

CBNumberCB9404885

SummenformelC22H28ClNO2

Molgewicht373.92

MOL-Datei134-63-4.mol

Synonyma

Lobelinhydrochlorid

Lobelinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	183-185 °C (dec.)(lit.)
alpha	D20 -43° (c = 2)
Brechungsindex	-57.5 ° (C=1, H2O)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	H₂O: 25 mg/mL
Aggregatzustand	powder
Farbe	white to off-white
Optische Aktivität	[α]20/D 56.8°, c = 2 in H2O
Merck	14,5551
BRN	3920196
LogP	3.610 (est)
CAS Datenbank	134-63-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/25
S-Sätze:	36/37/39-45
RIDADR	UN 1544 6.1/PG 3
WGK Germany	3
RTECS-Nr.	OJ8490100
F	8
HazardClass	6.1(b)
PackingGroup	III

Gefahreninformationscode (GHS)

alpha-Lobeline hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/25:Giftig beim Einatmen und Verschlucken.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities. It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (K_i = 4 nM) and has antinociceptive effects in the tail-flick assay in mice. (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats. It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
A neuronal nicotinic acetylcholine receptor agonist. A CNS stimulant.
Verwenden
A neuronal nicotinic acetylcholine receptor agonist. A respiratory stimulant
Biologische Aktivität
High affinity nicotinic receptor ligand, with a K i value of 4.4 nM in rat brain.
in vitro
clastogenicity of lobeline and possible interactions between lobeline and ethyl alcohol were investigated in a mutagen-sensitivity assay on cultures of human lymphoblastoid cell lines. lobeline alone was not clastogenic, but there was a marked increase in genetic damage resulting from a coclastogenic interaction between lobeline and ethyl alcohol. [5]
in vivo
male c57bl/6j mice were individually housed and acclimatized to 10% alcohol. lobeline is a partial nicotinic agonist that attenuates alcohol consumption and preference in male c57bl/6j mice. [3] cf-1 male mice received an intraperitoneal injection of lobeline (5 or 10mg/kg). lobeline did not show genotoxic or mutagenic effects and did not increase the ethanol-induced genotoxic effects in blood. lobeline also protected blood cells against oxidative damage induced by hydrogen peroxide. [4]

alpha-Lobeline hydrochloride Upstream-Materialien And Downstream Produkte

Lobelinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

134-63-4, alpha-Lobeline hydrochloride Verwandte Suche:

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