Ranolazine dihydrochloride

Bezeichnung:Ranolazine dihydrochloride

CAS-Nr95635-56-6

Englisch Name:Ranolazine dihydrochloride

CBNumberCB8195173

SummenformelC24H35Cl2N3O4

Molgewicht500.46

MOL-Datei95635-56-6.mol

Ranolazine dihydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	222-229.5 °C(lit.)
storage temp.	Desiccate at RT
Löslichkeit	H₂O: 10 mg/mL, soluble
Aggregatzustand	solid
Farbe	off-white
Wasserlöslichkeit	H2O: soluble ≥10mg/mL
Merck	14,8111
Stabilität	Hygroscopic
CAS Datenbank	95635-56-6(CAS DataBase Reference)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	TK7845370
HS Code	29335990

Gefahreninformationscode (GHS)

Ranolazine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (I_Na) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Na_v1.5 channels (IC₅₀s = 5.9-15 μM) as well as the late potassium current (I_Kr) in canine ventricular myocytes and HEK293 cells (IC₅₀s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α₁-, β₁-, and β₂-adrenergic receptors (K_is = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .
Chemische Eigenschaften
White Crystalline Powder
Verwenden
Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.
Verwenden
treatment of angina and congestive heart failure
Biologische Aktivität
Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.
Biochem/physiol Actions
Ranolazine is a derivative of anti-ischemic piperazine and acts as sodium (Na+)-current inhibitor. It has the potential to treat diastolic heart failure and helps in ameliorating myocardial diastolic function.
Lager
Desiccate at RT

Ranolazine dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

95635-56-6, Ranolazine dihydrochloride Verwandte Suche:

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