1-(9H-fluoren-9-ylmethyl)-(S)-hydrogenpyrrolidin-1,2-dicarboxylat

Bezeichnung:1-(9H-fluoren-9-ylmethyl)-(S)-hydrogenpyrrolidin-1,2-dicarboxylat

CAS-Nr71989-31-6

Englisch Name:Fmoc-Pro-OH

CBNumberCB8189794

SummenformelC20H19NO4

Molgewicht337.37

MOL-Datei71989-31-6.mol

Synonyma

1-(9H-fluoren-9-ylmethyl)-(S)-hydrogenpyrrolidin-1,2-dicarboxylat

1-(9H-fluoren-9-ylmethyl)-(S)-hydrogenpyrrolidin-1,2-dicarboxylat physikalisch-chemischer Eigenschaften

Schmelzpunkt	117-118 °C(lit.)
alpha	-32 º (c=1,DMF)
Siedepunkt	473.68°C (rough estimate)
Dichte	1.2486 (rough estimate)
Brechungsindex	-32.5 ° (C=1, DMF)
storage temp.	Store below +30°C.
Löslichkeit	Soluble in methanol. (almost transparency.)
pka	3.95±0.20(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Optische Aktivität	[α]20/D 32±1°, c = 1% in DMF
BRN	3596735
Concentration	0.1 mCi/ml
Solvent	Ethanol
Specific Activity	50-60 mCi/mmol
CAS Datenbank	71989-31-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-24/25
WGK Germany	3
HS Code	2933 99 80

Gefahreninformationscode (GHS)

Fmoc-Pro-OH Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Fmoc-Pro-OH is easily dissolved in DMF or NMP. Proline fails to produce a blue-to purple color in the Kaiser test. The Isatin test may be used to test the completion of couplings to proline residues.
Chemische Eigenschaften
white to light yellow crystal powder.
Verwenden
L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
synthetische
To a solution of (S)-pyrrolidine-2-carboxylic acid (1 g, 8.7 mmol) in 1,4-dioxane (4 mL) and water (15 mL), K2CO3 (3.24 g, 23 mmol) was added, followed by the addition of 9-fluorenylmethyl chloroformate (2.3 g, 8.3 mmol). The resulting mixture was stirred overnight at room temperature and then treated with water (10 mL). The resulting mixture was extracted with diethyl ether (2 x 20 mL), and the aqueous phase was made acidic with 1M HCl to a pH of 2-3, followed by extraction with dichloromethane (3 x 50 mL). The combined organic layers were dried using anhydrous sodium sulfate and concentrated to yield Fmoc-Pro-OH as a white solid in a 95% yield (2.8 g).
Allgemeine Beschreibung
The product number for this product was previously 04-12-1031.

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Fmoc-Pro-OH Upstream-Materialien And Downstream Produkte

1-(9H-fluoren-9-ylmethyl)-(S)-hydrogenpyrrolidin-1,2-dicarboxylat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

71989-31-6, Fmoc-Pro-OH Verwandte Suche:

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