MELITTIN

Bezeichnung:MELITTIN

CAS-Nr20449-79-0

Englisch Name:MELITTIN

CBNumberCB4388272

SummenformelC131H229N39O31

Molgewicht2846.46

MOL-Datei20449-79-0.mol

MELITTIN physikalisch-chemischer Eigenschaften

alpha	D21 -89.52° (c = 0.409)
Dichte	1.39
storage temp.	-20°C
Löslichkeit	Soluble to 1 mg/ml in 20% acetonitrile
Aggregatzustand	White to faint tan powder.
Farbe	White to off-white
Wasserlöslichkeit	Soluble to 1 mg/ml in water
Sequenz	H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
InChIKey	VDXZNPDIRNWWCW-JFTDCZMZSA-N

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25
S-Sätze:	36-45-36/37/39
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS-Nr.	OS3965000
F	10-21

Gefahreninformationscode (GHS)

MELITTIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
Melittin from honey bee venom has been used:
- In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
- To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
- As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.
Verwenden
Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions.
Definition
ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active com onent of bee venom.
Allgemeine Beschreibung
Chemical structure: peptide
Biochem/physiol Actions
Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death.
Lager
Store at -20°C

MELITTIN Upstream-Materialien And Downstream Produkte

MELITTIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

20449-79-0, MELITTIN Verwandte Suche:

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