4-Methylpyridazin-3,6-diol

Bezeichnung:4-Methylpyridazin-3,6-diol

CAS-Nr5754-18-7

Englisch Name:3,6-Dihydroxy-4-methylpyridazine

CBNumberCB7192377

SummenformelC5H6N2O2

Molgewicht126.11

MOL-Datei5754-18-7.mol

Synonyma

4-Methylpyridazin-3,6-diol

4-Methylpyridazin-3,6-diol physikalisch-chemischer Eigenschaften

Schmelzpunkt	284-288 °C
Dichte	1.226±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Aggregatzustand	powder to crystal
pka	9.34±0.40(Predicted)
Farbe	White to Light yellow
CAS Datenbank	5754-18-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26
WGK Germany	3
HS Code	29339900

Gefahreninformationscode (GHS)

3,6-Dihydroxy-4-methylpyridazine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White powder
Synthese

616-02-4

5754-18-7

The general procedure for the synthesis of 4-methylpyridazine-3,6-dione from citraconic anhydride was as follows: citraconic anhydride (24.0 mL, 270 mmol) was slowly added dropwise to a mixture of ice-bath-cooled hydrazine (4 M aqueous solution buffered to pH 6.5 by AcOH; 200 mL) and ethanol (250 mL), and the reaction mixture appeared to be in a light-yellow heterogeneous state. Subsequently, the mixture was heated under mild reflux conditions for 24 hours. Upon completion of the reaction, the mixture was allowed to cool to room temperature and the ethanol was evaporated under reduced pressure to give a white heterophase mixture. This mixture was diluted with water (250 mL) and the resulting white precipitate was collected by filtration. The precipitate was washed with water, placed on phosphorus pentoxide and dried under vacuum at room temperature for 24 h. A white powder of 4-methylpyridazine-3,6-dione was finally obtained (21.8 g; 65% yield). The product was characterized by 1H NMR (200 MHz, DMSO-d6): δ 2.00 (3H, s), 6.85 (1H, s), 11.22 (2H, brs).
Einzelnachweise
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1644 - 1658
[2] Journal of the American Chemical Society, 1954, vol. 76, p. 4454,4457
[3] Zhurnal Obshchei Khimii, 1954, vol. 24, p. 1216,1219; engl. Ausg. S. 1205, 1206
[4] Journal of the American Chemical Society, 1954, vol. 76, p. 2201
[5] Journal of Organic Chemistry, 1954, vol. 19, p. 115,117

3,6-Dihydroxy-4-methylpyridazine Upstream-Materialien And Downstream Produkte

4-Methylpyridazin-3,6-diol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5754-18-7, 3,6-Dihydroxy-4-methylpyridazine Verwandte Suche:

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