4-NITRO-PYRIDIN-2-YLAMINE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

4-NITRO-PYRIDIN-2-YLAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Verwenden

  4-Nitropyridin-2-amine is used to synthesize tetrahydronaphthalene Raf inhibitors.

• Synthese

  

  942076-74-6

  

  4487-50-7

  Step 3: Synthesis of 4-nitropyridine-2-amino intermediate-22 N-(4-methoxybenzyl)-4-nitropyridin-2-amine (Int-21, 27.8 g, 0.11 mol) and anisole (13 mL, 0.12 mol) were dissolved in trifluoroacetic acid (112 mL) and the reaction was heated at 80 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated. The resulting residue was ground with EtOAc and hexane to give a pale yellow solid, which was separated by filtration. The filtrate was allowed to stand overnight to precipitate a second batch of crystals. The two solid batches were combined, dissolved in 1N NaOH solution (250 mL) and extracted with EtOAc (2 x 250 mL). The organic phases were combined, dried over magnesium sulfate, filtered and concentrated to give 4-nitropyridin-2-amine as an orange solid (10.2 g, 67% yield). LCMS (FA) ES+: m/z 140. 1H NMR (400 MHz, CD3OD) δ ppm: 8.15 (dd, J = 5.7, 0.6 Hz, 1H), 7.23 (dd, J = 2.0, 0.6 Hz, 1H), 7.20 (dd, J = 5.7, 2.0 Hz, 1H).

• Einzelnachweise

  [1] Patent: WO2011/146591, 2011, A1. Location in patent: Page/Page column 72-73
  [2] Patent: US2012/15942, 2012, A1. Location in patent: Page/Page column 51
  [3] Patent: EP3305788, 2018, A1. Location in patent: Paragraph 0059; 0062
  [4] Journal of Medicinal Chemistry, 2011, vol. 54, # 6, p. 1836 - 1846

4-NITRO-PYRIDIN-2-YLAMINE Upstream-Materialien And Downstream Produkte

4-NITRO-PYRIDIN-2-YLAMINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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