Procainamidhydrochlorid

Bezeichnung:Procainamidhydrochlorid

CAS-Nr614-39-1

Englisch Name:Procainamide hydrochloride

CBNumberCB7139464

SummenformelC13H22ClN3O

Molgewicht271.79

MOL-Datei614-39-1.mol

Synonyma

Procainamidhydrochlorid

Procainamidhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	165-168 °C
Dichte	1.2027 (rough estimate)
Brechungsindex	1.6330 (estimate)
storage temp.	2-8°C
Löslichkeit	H2O: soluble1g/10 mL, clear, greenish-yellow
Aggregatzustand	Powder
Farbe	White to slightly yellow
Wasserlöslichkeit	soluble
Sensitive	Light Sensitive/Air Sensitive
Merck	13,7845
BRN	3729517
CAS Datenbank	614-39-1(CAS DataBase Reference)
EPA chemische Informationen	Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride (614-39-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	CV2295000
HS Code	29242990

Gefahreninformationscode (GHS)

Procainamide hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Procainamide (hydrochloride) (Item No. 24359) is an analytical reference standard categorized as a local anesthetic. This product is intended for research and forensic applications.
Chemische Eigenschaften
White to slightly yellow powder
Verwenden
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Verwenden
Procainamide hydrochloride (PAH) is suitable to investigate its binding behavior with human serum albumin and bovine serum albumin by fluorescence quenching study to understand the pharmacokinetic and pharmacodynamic mechanisms of PAH.
Verwenden
Class I antiarrhythmic
Definition
ChEBI: A hydrochloride which has procainamide as the amino component.
Allgemeine Beschreibung
Procainamide hydrochloride,p-amino-N-[2-(diethylamino)ethyl]benzamidemonohydrochloride, procainamidium chloride (Pronestyl,Procan SR), has emerged as a major antiarrhythmic drug. Itwas developed in the course of research for compoundsstructurally similar to procaine, which had limited effectas an antiarrhythmic agent because of its central nervoussystem (CNS) side effects and short-lived action causedby rapid hydrolysis of its ester linkage by plasma esterases.Because of its amide structure, procainamide hydrochlorideis also more stable in water than is procaine. Aqueoussolutions of procainamide hydrochloride have a pH ofabout 5.5. A kinetic study of the acid-catalyzed hydrolysisof procainamide hydrochloride showed it to be unusuallystable to hydrolysis in the pH range 2 to 7, even at elevatedtemperatures.
Biochem/physiol Actions
Procainamide hydrochloride is a sodium channel blocker and Class IA anti-arrhythmic. It has also been shown to Inhibit DNA methyltransferase and modulate epigenetic regulation of gene expression.
Clinical Use
Procainamide hydrochloride is metabolized through theaction of N-acetyltransferase. The product of enzymaticmetabolism of procainamide hydrochloride is N-acetylprocainamide(NAPA), which possesses only 25% of the activityof the parent compound.26 A study of the disposition ofprocainamide hydrochloride showed that 50% of the drugwas excreted unchanged in the urine, with 7% to 24% recoveredas NAPA.28,29 Unlike quinidine, procainamide hydrochlorideis bound only minimally to plasma proteins.Between 75% and 95% of the drug is absorbed from the gastrointestinaltract. Plasma levels appear 20 to 30 minutesafter administration and peak in about 1 hour.30Procainamide hydrochloride appears to have all of theelectrophysiological effects of quinidine. It diminishesautomaticity, decreases conduction velocity, and increasesaction potential duration and, thereby, the refractory periodof myocardial tissue. Clinicians have favored the use of procainamidehydrochloride for ventricular tachycardias andquinidine for atrial arrhythmias, even though the two drugsare effective in either type of disorder.
Veterinary Drugs and Treatments
Procainamide potentially may be useful for the treatment of ventricular premature complexes (VPC’s), ventricular tachycardia, or supraventricular tachycardia associated with Wolff-Parkinson- White (WPW) syndrome with wide QRS complexes. Higher doses may be beneficial in the treatment of supraventricular tachycardias, although procainamide cannot be considered a first-line agent for this dysrhythmia.

Procainamide hydrochloride Upstream-Materialien And Downstream Produkte

Procainamidhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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