Beclobrat

Bezeichnung:Beclobrat

CAS-Nr55937-99-0

Englisch Name:Beclobrate

CBNumberCB6875424

SummenformelC20H23ClO3

Molgewicht346.85

MOL-Datei55937-99-0.mol

Synonyma

Beclobrat

Beclobrat physikalisch-chemischer Eigenschaften

Siedepunkt	bp0.01-0.1 200-204°
storage temp.	2-8°C

Sicherheit

Toxizität

LD50 orally in mice: 8000 mg/kg (Thiele, 1979)

Beclobrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Beclobrate is a hypolipidemic agent related structurally to clofibrate. It is reportedly useful in types IIa-V hyperlipoproteinemias, promoting normalization of t h e atherogenic index.
Originator
Siegfried AG (Switzerland)
Definition
ChEBI: Beclobrate is a diarylmethane.
Manufacturing Process
87.0 g (0.4 mol) of 4-chloro-4'-hydroxydiphenylmethane are heated together with 27.0 g (0.2 mol) of anhydrous potassium carbonate in 350 ml of anhydrous xylene for 30 min to reflux temperature, whereafter a solution of 83.5 g (0.4 mol) of 2-bromo-2-ethyl-2-methyl acetic acid ethyl ester in 50 ml of anhydrous xylene is added. The mixture is kept for 24 hours and with vigorous stirring at reflux temperature. After filtering off the precipitated potassium bromide and evaporating the solvent in a Buchi rotary evaporator, the residue is taken up in ether and extracted with normal sodium hydroxide solution. The ether extracts are washed with water, dried over MgSO4 and concentrated by evaporation. The brown oil (82.0 g) thereby obtained is dissolved in n-hexane and filtered through a column of 200 g of basic Al2O3. After evaporating the solvent and distillation at reduced pressure, 34.7 g of pure ethyl (+/-)-2-((α-(p-chlorophenyl)-p-tolyl)oxy)-2-methylbutyrate are obtained with the boiling point 200-204°C/0.01-0.1 mm Hg.
Trademarks
BECLOSCLERIN
Therapeutic Function
Antihyperlipidemic
Weltgesundheitsorganisation (WHO)
Beclobrate, an antihyperlipidaemic agent, was introduced into medicine in 1985. Although a causal relationship between the use of the drug and hepatic toxicity has not been established, the Intercantonal Office for the Control of Medicines has withdrawn marketing authorization since safer therapeutic alternatives are available. Beclobrate is not registered elsewhere.

Beclobrate Upstream-Materialien And Downstream Produkte

Beclobrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

55937-99-0, Beclobrate Verwandte Suche:

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