Amitrol (ISO)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

3-Amino-1,2,4-Triazole Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  GERUCHLOSE FARBLOSE KRISTALLE.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen unter Bildung giftiger Rauche mit Stickstoffoxiden. Schwache Base. Reagiert mit starken Säuren, starken Oxidationsmitteln, Säurechloriden und Säureanhydriden. Greift Eisen, Kupfer und Aluminium an.

• ARBEITSPLATZGRENZWERTE

  TLV: 0,2 mg/m?(als TWA); Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
  MAK: 0,2 mg/m?(Einatembare Fraktion); Spitzenbegrenzung: überschreitungsfaktor II(8); Krebserzeugend Kategorie 3B; Schwangerschaft: Gruppe C; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation des Aerosols und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Möglich sind Auswirkungen auf die Schilddrüse.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Möglich sind Auswirkungen auf die Schilddrüse mit nachfolgender Kropfbildung.

• LECKAGE

  NICHT in die Kanalisation spülen. Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P3-Filter für giftige Partikel.

• R-Sätze Betriebsanweisung:

  R48/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
  R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R63:Kann das Kind im Mutterleib möglicherweise schädigen.
  R40:Verdacht auf krebserzeugende Wirkung.

• S-Sätze Betriebsanweisung:

  S13:Von Nahrungsmitteln, Getränken und Futtermitteln fernhalten.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

• Chemische Eigenschaften

  Amitrole is a colorless to off-white crystalline solid or white powder. Odorless when pure.

• Chemische Eigenschaften

  white powder or crystals

• Verwenden

  catalase inhibitor

• Verwenden

  Herbicide; plant regulator.

• Verwenden

  Nonselective, foliage-applied, systemic, triazole herbicide used in uncropped land and orchards to control certain grasses and to kill annual and perennial grasses and weeds. It is also effective on poison ivy, poison oak and aquatic weeds

• Definition

  A powerful plant growth suppressant and cotton defoliant that is readily absorbed by leaves and roots. 3-Amino-1,2,4-Triazole inhibits many aspects of growth and differentiation including cell division in the primary root meristems in some plants.

• Vorbereitung Methode

  3-Amino-1,2,4-Triazole（Amitrole） is synthesized by condensing formic acid with aminoguanidine and can be purified by recrystallization from methanol.

• Allgemeine Beschreibung

  Odorless white crystals or white powder. Bitter taste. Melting point 147-159°C. Sublimes undecomposed at reduced pressure. Used as a post-emergence herbicide.

• Air & Water Reaktionen

  Water soluble. Aqueous solutions are neutral. Dust may form an explosive mixture in air.

• Reaktivität anzeigen

  3-Amino-1,2,4-Triazole is a triazole derivative. The triazoles are a group that contain several derivatives that are highly explosive materials. They are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. It forms chelates with some metals. 3-Amino-1,2,4-Triazole is corrosive to iron, copper and aluminum. Forms salts with most acids and alkalis. It is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides .

• Hazard

  Toxic; carcinogen.

• Health Hazard

  Amitrole (3-Amino-1,2,4-Triazole) has low acute toxicity; in experimental animal studies subchronic exposures were associated with changes in the thyroid and chronic exposures were carcinogenic.
  Intentional ingestion of a mixture that contained 20 mg/kg amitrole did not cause any signs of intoxication.1 In one reported case study, inhalation of a large amount of amitrolecontaining herbicide was associated with acute toxic reaction of the lungs.2 Lung injury was thought to be secondary to direct toxic damage to the alveolar lining cells. The remarkable lack of any other reports describing pulmonary toxicity of this herbicide was noted, in addition to the presence of other chemicals in the herbicide solution.

• Brandgefahr

  Literature sources indicate that Triazol-3-amine is non-combustible.

• Landwirtschaftliche Anwendung

  Herbicide, Plant growth regulator: A non-food use herbicide for control of grasses, woody plants and broad-leaf weeds on hard surface and in areas where crops are not normally grown.

• Handelsname

  AMITRIL®; ATLAZIN®; ATLAZINE® FLOWABLE; AT®; 3-AT®; AT-90®; ATRAFLOW PLUS®; AZAPLANT®; AZAPLANT KOMBI®; AZOLAN®; AZOLE®; BOROFLOW® A/ATA; CAMPAPRIM® A 1544; CDA SIMFLOW PLUS®; CHIPMAN® PATH; CYTROLE®; DIUROL® AMITROLE; DOMATOL®; ELMASIL®; EMISOL®; FARMCO®; HERBAZIN PLUS SC®; HERBICIDE® TOTAL; MASCOT HIGHWAY®; MSS AMINOTRIAZOLE®; MSS SIMAZINE®; ORGA-414®; RADOXONE® TL; RAMIZOL®; RASSAPRON®; SIMAZOL®; SIMFLOW PLUS®; SOLUTION CNCENTREE T271®; SYNCHEMICALS® TOTAL WEED KILLER; SYNTOX®; TORAPRON®; VOROX®; WEEDAR®; WEEDAZIN®; WEEDAZOL TL ®; WEEDOCLOR®

• Biochem/physiol Actions

  BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors.Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments.

• Sicherheitsprofil

  Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,. An herbicide and plant growth regulator

• mögliche Exposition

  A potential danger to those involved in the manufacture, formulation, and application of this postemergence herbicide, which is now limited to noncrop applications as a herbicide and plant growth regulator. Some triazoles have been used as rubber components.

• Carcinogenicity

  Amitrole is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• Environmental Fate

  Soil. When radiolabeled amitrole-5-14C was incubated in a Hagerstown silty clay loam, 50 and 70% of the applied amount evolved as 14CO2 after 3 and 20 days, respectively. In autoclaved soil, however, no 14CO2 was detected. The chemical degradation in soil was probably via hydroxyl radicals (Kaufman et al., 1968). The average persistence in soils is 2–4 weeks (Hartley and Kidd, 1987)
  Plant.Amitrole is transformed in plants to form the conjugate β-(3-amino-1,2,4-triazol- 1-yl)-α-alanine (Humburg et al., 1989) and/or 3-(3-amino-s-triazole-1-yl)-2-aminopropionic acid (Duke et al., 1991). Amitrole is metabolized in Canada thistl
  Surface Water. In pond water, adsorption to suspended sediments was an important process. The initial half-life was reported to be no more than 68 days. After 120 days, 20% of the applied amount remained (Grzenda et al., 1966). The biodegradation
  Photolytic. Direct photolysis of amitrole is not expected to occur since the herbicide shows little or no absorption greater than 295 nm (Gore et al., 1971)
  Chemical/Physical. Reacts with acids and bases forming soluble salts (Hartley and Kidd, 1987). Emits toxic fumes of nitrogen oxides when heated to decomposition (Sax and Lewis, 1987); however, incineration with polyethylene results in more than 9

• Versand/Shipping

  UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

• läuterung methode

  It crystallises from EtOH (charcoal), then three times from dioxane [Williams et al. J Phys Chem 61 261 1957]. [Beilstein 26 H 137.] Possible carcinogen. [Beilstein 26 H 137, Temple & Montgomery 1,2,4-Triazoles —The Chemistry of Heterocyclic Compounds Vol 37 (Weissberger & Taylor eds.). Wiley & Sons NY 1981, ISBN 0-471-0656-6.]

• Inkompatibilitäten

  Dust may be explosive in air. Keep away from strong oxidizers; strong acids; light and heat (decomposes). Corrosive to iron, aluminum, and copper. Sublimes undecomposed at reduced pressure.

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Amitrol is resistant to hydrolysis and the action of oxidizing agents. Burning the compound with polyethylene is reported to result in .99% decomposition.

3-Amino-1,2,4-Triazole Upstream-Materialien And Downstream Produkte

Amitrol (ISO) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(553)Suppliers

61-82-5, 3-Amino-1,2,4-Triazole Verwandte Suche: