Prednison Produkt Beschreibung

Prednisone Struktur
53-03-2
  • CAS-Nr.53-03-2
  • Bezeichnung:Prednison
  • Englisch Name:Prednisone
  • Synonyma:Prednison
    MOPP;u6020;Cortan;Deltra;Cotone;deltae;U 6020;Wojtab;delta-E;In-Sone
  • CBNumber:CB6716222
  • Summenformel:C21H26O5
  • Molgewicht:358.43
  • MOL-Datei:53-03-2.mol
Prednison physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :236-238 °C(lit.)
  • alpha  :169 º (c=0.5, dioxane)
  • Siedepunkt: :410.86°C (rough estimate)
  • Dichte :1.1121 (rough estimate)
  • Brechungsindex :170 ° (C=0.5, Dioxane)
  • Flammpunkt: :>200℃
  • storage temp.  :2-8°C
  • Löslichkeit :Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
  • pka :12.36±0.60(Predicted)
  • Wasserlöslichkeit :115mg/L(25 ºC)
  • Merck  :7722
  • BRN  :2065301
  • Stabilität: :Stable. Incompatible with strong oxidizing agents.
  • CAS Datenbank :53-03-2(CAS DataBase Reference)
  • IARC :3 (Vol. 26, Sup 7) 1987
  • NIST chemische Informationen :Prednisone(53-03-2)
  • EPA chemische Informationen :Prednisone (53-03-2)
Sicherheit

Prednisone Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R63:Kann das Kind im Mutterleib möglicherweise schädigen.
    R34:Verursacht Verätzungen.
    R11:Leichtentzündlich.
  • S-Sätze Betriebsanweisung: S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S16:Von Zündquellen fernhalten - Nicht rauchen.
  • Chemische Eigenschaften White or almost white, crystalline powder.
  • Verwenden Adrenocortical steroid. Glucocorticoid, antiinflammatory.
  • Verwenden Downregulates TNF-α production and NF-κB expression
  • Verwenden Prednisone is used for the same indications as cortisone for inflammatory processes, allergies, and adrenal gland insufficiency; however, it is somewhat more active than cortisone and has less of an effect on mineral volume.
  • Indications Prednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.
  • Definition ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.
  • Trademarks Cortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).
  • Allgemeine Beschreibung Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.
  • Allgemeine Beschreibung Odorless white crystalline powder.
  • Air & Water Reaktionen Very slightly water soluble .
  • Hazard Questionable carcinogen.
  • Sicherheitsprofil Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.
  • Chemical Synthesis Prednisone is 17α,21-dihydroxypregna-1,4-dien-3,11-20-trione (27.1.31). Prednisone differs from cortisone in the presence of an additional double bond between C1 and C2. There are various ways of synthesizing it. In one of these, as is in the case when synthesizing cortisone, it is synthesized from dihydrocortisone acetate. However, in the given example, this compound undergoes dibromination by molecular bromine, giving 2,4-dibromo-derivative of dihydrocortisone 27.1.30. Dehydrobromination with 3,5-lutidine, followed by subsequent hydrolysis of the acetyl group using potassium bicarbonate gives the desired prednisone (27.1.31). Prednisone is also synthesized by microbiological dehydrogenation of cortisone.

  • läuterung methode Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]
Prednisone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Prednison Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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53-03-2, Prednisone Verwandte Suche:
  • 1,2-Dehydrocortisone
  • 1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione
  • 11,20-trione,17,21-dihydroxy-pregna-4-diene-3
  • 11,20-trione,17,21-hydroxy-pregna-4-diene-3
  • Ancortone
  • Bicortone
  • Colisone
  • Cortan
  • Cortancyl
  • Cortidelt
  • delta-E
  • Deltasone
  • delta-sone
  • Deltison
  • Deltisone
  • Deltra
  • Di-Adreson
  • Encorton
  • Encortone
  • Enkorton
  • Hostacortin
  • In-Sone
  • Juvason
  • Lisacort
  • meburamide
  • Metacortandracin
  • Meticorten
  • NCI-C04897
  • nci-co4897
  • NSC 10023
  • nsc10023
  • Orasone
  • Paracort
  • Precort
  • Prednicen-M
  • Prednilonga
  • Prednizon
  • 1,4-PREGNADIENE-17ALPHA,21-DIOL-3,11,20-TRIONE
  • (8S,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-7,8,9,10,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,11-DIONE
  • PREDNISONE, PH EUR
  • Prednisone,98%
  • 1,4-Pregnadiene-17a,21-diol-3,11,20-trione
  • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
  • 1,4-pregnadiene-17α,21-diol-3,11,20-trione
  • PREDNISONE,ANHYDROUS,MICRONIZED,USP
  • PREDNISONE,ANHYDROUS,POWDER,USP
  • MOPP
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone, Prednisonum
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
  • Apo-Prednisone
  • Ancotone
  • 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
  • Prednisolone EP Impurity B
  • Prednisolone Impurity 2(Prednisolone EP Impurity B)
  • Cotone
  • Dacortin
  • Decortancyl
  • Decortin