Metamizole Sodium Monohydrate

Bezeichnung:Metamizole Sodium Monohydrate

CAS-Nr5907-38-0

Englisch Name:Metamizole Sodium Monohydrate

CBNumberCB6715922

SummenformelC13H20N3NaO5S

Molgewicht353.37

MOL-Datei5907-38-0.mol

Metamizole Sodium Monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	221℃
storage temp.	2-8°C
Löslichkeit	H2O: soluble25mg/mL, clear
Aggregatzustand	powder
Farbe	white to beige
BRN	3865381
CAS Datenbank	5907-38-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	63
S-Sätze:	36/37
WGK Germany	3
RTECS-Nr.	PB1320000

Gefahreninformationscode (GHS)

Metamizole Sodium Monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, crystalline powder
Verwenden
antibacterial
Verwenden
Metamizol Sodium Monohydrate is used in methods of using Metamizole for treatment of Pyrexia in equines.
Definition
ChEBI: Sulpyrine is an organic molecular entity.
Trademarks
Diprofarn (Farmitalia, Societa Farmaceutici Italia, Italy); Novaldin (Sterling Winthrop).
Allgemeine Beschreibung
Metamizole sodium is a nonsteroidal anti-inflammatory drug (NSAID). It is widely used as an analgesic and antipyretic agent.
Biochem/physiol Actions
Metamizole (Dipyrone) is a potent analgesic and antipyretic. Metamizole inhibits prostaglandin synthesis in both the periphery and the central nervous system. Metamizole may act as a prodrug. It is rapidly hydrolyzed to N-methyl-4-aminoantipyrine (MAA) and 4-aminoantipyrine (AA) which inhibit cyclo-oxygenase activity and can be further acylated with arachidonic acid forming compounds that bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors. It is believed that these metabolites play a major role in metamizole activity. Metamizole has been withdrawn from clinical use in several countries because of a side-effect of agranulocytosis in some patients.
Clinical Use
Metamizol is the water soluble sodium sulfonate of amidopyrine. After oral application it is rapidly hydrolyzed to 4-methylaminoantipyrine and metabolized to various active metabolites . Metamizol has strong analgesic, spasmolytic, and antipyretic, but no anti-inflammatory properties. The exact mechanism of action is unknown but may include inhibition of prostaglandin synthesis. Inhibition of both COX isoenzymes by metamizol has been demonstrated only when very high concentrations of this drug were used, thus questioning the relevance of this activity.
COX inhibition may be induced by the metabolites, but this is not yet systematically investigated. Metamizol is used for the treatment of medium to severe pain, often in combination with opioids, for fever reduction and for the treatment of colic pain. It is given by mouth in doses of 500 mg up to 4 g daily, by intravenous or by rectal application. Metamizol is relatively free of acute side effects but in rare cases may cause severe and life-threatening allergic reactions like agranulocytosis, allergic skin reactions, and allergic shock. The compound is not used in the UK, USA, and in Scandinavian countries.

Metamizole Sodium Monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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