Phosmet (ISO)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

  H332：Gesundheitsschädlich bei Einatmen.

  H370：Schädigt die Organe.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P273：Freisetzung in die Umwelt vermeiden.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Phosmet Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSEBIS GRAUWEISSE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen oder Verbrennen unter Bildung giftiger Rauche mit Stickstoffoxiden, Phosphoroxiden und Schwefeloxiden.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt (ACGIH 2005).
  MAK nicht festgelegt (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Eine gesundheitsschädliche Partikelkonzentration in der Luft kann beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Möglich sind Auswirkungen auf das Nervensystem mit nachfolgenden Krämpfen und Atemdepression. Cholinesterasehemmer. Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Möglich sind Auswirkungen auf das Nervensystem mit nachfolgender Schwäche. Cholinesterasehemmer. Kumulative Wirkung möglich (s. AKUTE GEFAHREN/SYMPTOME).

• LECKAGE

  Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät. NICHT in die Umwelt gelangen lassen. Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen.

• R-Sätze Betriebsanweisung:

  R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

• Beschreibung

  Phosmet is an organophosphate insecticide and acaricide. It reduces apple damage by a large variety of insects, including apple maggots, codling moths, and obliquebanded leafrollers when used as either a border or cover spray at a concentration of 1.9 kg AI/hectare. Phosmet is effective in controlling S. scabiei in pigs when applied as a 20% pour-on solution. It is toxic to rats via oral administration (LC₅₀ = 230 mg/kg). Formulations containing phosmet have been used in the control of insects and mites in agriculture.

• Chemische Eigenschaften

  Phosmet is a white crystalline solid

• Verwenden

  Insecticide, acaricide.

• Verwenden

  Phosmet is used as a pesticide to protect crops and vegetation. Insecticide.

• Verwenden

  Nonsystemic acaricide and insecticide used on citrus, fruit, grape and potato crop

• Verwenden

  Phosmet is used to control a wide range of insects and mites in fruit, potatoes, sweet potatoes, vines, cotton and many other crops. It is also used as a veterinary ectoparasiticide.

• Definition

  ChEBI: Phosmet is an organic thiophosphate, an organothiophosphate insecticide and a member of phthalimides. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to a N-(hydroxymethyl)phthalimide.

• Allgemeine Beschreibung

  Off-white crystalline solid with an offensive odor. Used as an insecticide and acaricide.

• Reaktivität anzeigen

  Organophosphates, such as Phosmet, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Storage above 113 F, may lead to decomposition. [EPA, 1998].

• Health Hazard

  Phosmet is an organophosphorus pesticide. Phosmet is very toxic; the probable oral lethal dose for humans is 50-500 mg/kg, or between 1 teaspoon and 1 oz. for a 150 lb. person. It is a cholinesterase inhibitor and has central nervous system effects. Oral lethal doses in humans have been reported at 50 mg/kg.

• Brandgefahr

  (Non-Specific -- Organophosphorus Pesticide, n.o.s.). Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Storage above 113F, may lead to decomposition.

• Landwirtschaftliche Anwendung

  Insecticide, Acaricide: Phosmet is a non-systemic insecticide used on both plants and animals. It is mainly used on apple trees for control of coddling moth, though it is also used on a wide range of crops including alfalfa, nuts, grapes, blueberries, peas, potatoes, fruit crops, ornamentals, and vines for the control of aphids, suckers, mites, fire ants and fruit flies. The compound is also an active ingredient in some dog collars. It is used as an insecticide on swine and cattle. U.S. Maximum Allowable Residue Levels for Phosmet [40 CFR 180.261 (a)]: Alfalfa 40 ppm; almond, hulls 10 ppm; apple 10 ppm; apricot 5 ppm; blueberry 10 ppm; cattle, fat 0.2 ppm; cattle, meat 0.2 ppm; cattle, meat byproducts 0.2 ppm; cherry 10 ppm; cotton, undelinted seed 0.1 ppm; crabapple 20 ppm; cranberry 10 ppm; fruit, stone, group 12 5 ppm; goat, fat 0.2 ppm; goat, meat0.2 ppm; goat, meat byproducts 0.2 ppm; grape 10 ppm; hog, fat 0.2 ppm; hog, meat 0.2 ppm; hog, meat byproducts 0.2 ppm; horse, fat 0.2 ppm; horse, meat 0.2 ppm; horse, meat byproducts 0.2 ppm; kiwifruit 25 ppm; nectarine 5 ppm; nuts 0.1 ppm; pea 0.5 ppm; pea, field, hay 10 ppm; pea, field, vines 10 ppm; peach 10 ppm; pear 10 ppm; pistachio 0.1 ppm; plum, prune, fresh 5 ppm; potato 0.1 ppm; sheep, fat 0.2 ppm; sheep, meat 0.2 ppm; sheep, meat byproducts 0.2 ppm; sweet potato, roots 10 ppm. Regional registration, as defined in section 180.1(n) [40 CFR 180.261 (c)]: Crabapple 20 ppm; pistachio 0.1 ppm.

• Handelsname

  Trade Names: APPA®; DECEMTHION®; DELPHOS ®; FESDAN®; FIREBAN®; FTALOPHOS®; IMIDAN®; KEMOLATE®; PERCOLATE®; PMC®; PROLATE®[C]; R 1504®; SAFIDON®; SMIDAN®; STARBAR CATTLE DUST®[C]; STAUFFER R 1504®; VET-KEM®; ZEOCON®

• Sicherheitsprofil

  A human poison by ingestion. Poison experimentally by inhalation and ingestion routes. Moderately toxic by skin contact. Human systemic effects by inhalation: lachqmation, somnolence, and olfaction effects. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx. See also ESTERS.

• mögliche Exposition

  An organophosphorus insecticide and acaricide.

• Carcinogenicity

  No treatment-related increases in tumor incidence occurred in rats given a diet with 0, 20, 40,200, or 400 ppm (400 ppm terminated at 12 months) (equivalent to 0, 1.1, 1.8, 9.4, and 23 mg/kg/day in males and 0, 1.1, 2.1, 10.9, and 27 mg/kg/day in females) for 2 years .
  When mice were given diets with 0, 5, 25, or 100 ppm phosmet (approximately 0.75, 3.75, or 15.0 mg/kg/day) for 2 years, there was an increased incidence of hepatocellular tumors in males and mammary gland tumors in females .

• Environmental Fate

  Soil. In soils, phosmet is rapidly hydrolyzed to phthalimide (Camazano and Martin, 1980; Sánchez Camazano and Sánchez Martin, 1983). The rate of hydrolysis is greater in the presence of various montmorillonite clays and chloride salts. The calculated hydrolysis half-lives of phosmet in the presence of calcium, barium, copper, magnesium and nickel montmorillonite clays were 0.084, 0.665, 10.025, 16.926 and 28.738 days, respectively. Similarly, the half-lives of phosmet in the presence of copper, calcium, magnesium and barium chlorides were <0.020, 5.731, 10.680 and 12.242 days, respectively. In comparison, the hydrolysis of phosmet in a neutral water solution was 46.210 days (Sánchez Camazano and Sánchez Martin, 1983)
  Plant. In plants, phosmet is degraded to nontoxic compounds (Hartley and Kidd, 1987). Dorough et al. (1966) reported the half-life in Bermuda grass was 6.5 days. Half-life values ranged from 1.2 to 6.5 days (Dorough et al., 1966; Leuck and Bowman
  Chemical/Physical. Emits toxic fumes of phosphorus, nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987). Though no products were identified, the
  hydrolysis half-lives at 20°C were 7.0 days and 7.1 hours at pH 6.1 and pH 7.4, respectively. At 37.5°C and pH 7.4, the hydrolysis is 1.1 hours (Freed et al., 1979)

• Stoffwechselwegen

  The main degradative route of phosmet metabolism in plants and animals is similar with the compound being hydrolysed via attack on the carbonyl group of the phthaloyl moiety, yielding phthalamic acid which is further hydrolysed and decarboxylated to benzoic acid. It should be noted, however, that the studies on which the evidence for these metabolites is based are old and used paper chromatography for the main analytical evidence. A rather later study in rats identified N-hydroxymethylphthalimide and phthalimide as metabolites, implying a degradative hydrolytic route via attack on the N-methylene carbon atom. Oxidative desulfuration to the active acetylcholinesterase inhibitor phosmet oxon predominates over hydrolysis in insects and is responsible for the selectivity of the compound.

• Stoffwechsel

  Orally administered phosmet in mammals is rapidly degraded to phthalamic acid, phthalic acid, and phthalic acid derivatives, and the metabolites are excreted in the urine. Oxidative desulfuration to the oxon predominates over hydrolysis in insects. It is rapidly degraded in plants and soils.

• Versand/Shipping

  UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1Poisonous materials, Technical Name Required.

• Toxicity evaluation

  The acute oral LD₅₀ for rats is 113–160 mg/kg. Inhalation LC50 (1 h) for rats is 2.76 mg/L air. NOEL (2 yr) for rats is 40 mg/kg/d. ADI is 0.01 mg/kg bw.

• Degradation

  Phosmet is relatively stable in acid media but it is hydrolysed under basic conditions. The half-lives at pH values 4.5, 7 and 8.3 were 13 days, <12 hours and <4 hours, respectively (PM). Phosmet was hydrolysed under basic conditions to phthalamic acid (2), phthalic acid (3) and O,Odimethyl phosphorodithioate (4) indicating that nucleophic attack by OH^-occurs preferentially on the phthalimido carbonyl group rather than on phosphorus (Menn et al., 1965) (Scheme 1). The photolysis of an ether solution of phosmet irradiated in a quartz tube by unfiltered UV light from a mercury vapour lamp was investigated by Tanabe ef al. (1974). Photoproducts were separated by silica gel column chromatography and characterised by GLC, TLC, MS and ¹H NMR spectroscopy in comparison with authenticated reference standards. Two major photoproducts were identified as N-methylphthalimide (5) and N-methoxymethylphthalimide (6) (Scheme 1) in addition to a large number of minor products which were not characterised. The use of a Pyrex filter to remove light below 286 nm reduced the rate of photolysis but not the nature of the products. N-Methoxymethylphthalimide (6) was the main product when phosmet was irradiated by sunlight in thin films on silica gel TLC plates or in dilute aqueous solution [personal communication by McBain and Menn (1973), in Tanabe et al., 1974].

• Inkompatibilitäten

  Organothiophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrideds and active metals. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Not compatible with other pesticides under alkaline conditions. Contact with water, steam or moisture forms phthalic acids. Slightly corrosive to metals in the presence of moisture.

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Small amounts may be decomposed with hypochlorite. For large amounts, incineration with effective gas scrubbing is recommended.

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