Felodipine

Felodipine Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.

• Verwenden

  Vasodilator.

• Trademarks

  Plendil (AstraZeneca).

• Clinical Use

  Calcium-channel blocker:
  Hypertension
  Angina

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Aminophylline and theophylline: possibly increased aminophylline and theophylline concentration.
  Anaesthetics: enhanced hypotensive effect.
  Antibacterials metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin.
  Antidepressants: enhanced hypotensive effect with MAOIs.
  Antiepileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone.
  Antifungals: metabolism inhibited by itraconazole and ketoconazole; negative inotropic effect possibly increased with itraconazole.
  Antihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of postsynaptic alpha-blockers.
  Antivirals: concentration possibly increased by ritonavir; use with caution with telaprevir.
  Grapefruit juice: concentration increased - avoid concomitant use.
  Tacrolimus: possibly increased tacrolimus concentration

• Stoffwechsel

  Felodipine is metabolised in the liver and all identified metabolites are devoid of vasodilating properties. Approximately 70% of a given dose is excreted as metabolites in the urine and about 10% with the faeces. Less than 0.5% of the dose is excreted unchanged in the urin

Felodipine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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