Ethyl-2-(triphenylphosphoranyliden)propionat

Bezeichnung:Ethyl-2-(triphenylphosphoranyliden)propionat

CAS-Nr5717-37-3

Englisch Name:Ethyl 2-(triphenylphosphoranylidene)propionate

CBNumberCB6381055

SummenformelC23H23O2P

Molgewicht362.4

MOL-Datei5717-37-3.mol

Synonyma

Ethyl-2-(triphenylphosphoranyliden)propionat

Ethyl-2-(triphenylphosphoranyliden)propionat physikalisch-chemischer Eigenschaften

Schmelzpunkt	158-162 °C (lit.)
Siedepunkt	497.2±28.0 °C(Predicted)
Dichte	1.14±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Crystalline Powder
Farbe	Yellow
Wasserlöslichkeit	Soluble in water.
Sensitive	Air Sensitive
BRN	757112
InChIKey	KZENFXVDPUMQOE-UHFFFAOYSA-N
CAS Datenbank	5717-37-3(CAS DataBase Reference)
NIST chemische Informationen	Propanoic acid, 2-(triphenylphosphoranylidene)-, ethyl ester(5717-37-3)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	36/37/38-25
S-Sätze:	45-37/39-26
RIDADR	2811
WGK Germany	3
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	29319090

Gefahreninformationscode (GHS)

Ethyl 2-(triphenylphosphoranylidene)propionate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
yellow crystalline powder
Verwenden
(1-Ethoxycarbonylethylidene)triphenylphosphorane is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals. It?s also a Horner-Wadsworth-Emmons reagent. It can be used for olefination. It can also be utilized for the synthesis of more complex compounds, such as (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor.
Synthese
Ethyl 2-(triphenylphosphoranylidene)propionate was prepared this reagent from ethyl 2-bromopropanoate and triphenylphosphine.A 500-mL, one-necked, round-bottomed flask equipped with an egg-shaped magnetic stirring bar is charged with triphenylphosphine (52.46 g, 200.0 mmol), ethyl acetate (130 mL), and ethyl 2-bromopropanoate (26.03 mL, 200.0 mmol). A reflux condenser is attached to the flask and the solution is heated under reflux (oil bath temperature: 75-80 °C) under argon for 24 h. The resulting white precipitate is collected through suction filtration on a Büchner funnel and washed with ethyl acetate (100 mL). The salt is dissolved in dichloromethane (500 mL) and the solution is transferred to a 1-L separation funnel. Aqueous sodium hydroxide solution (2 M, 200 mL) is added and, after vigorously shaking, the organic and aqueous layers are separated. The aqueous phase is extracted with dichloromethane (100 mL). The combined organic phases are washed with brine, dried over anhydrous Na₂SO₄, filtered, and concentrated at 30 °C under rotary evaporation (20-25 mmHg); drying under vacuum (0.1-0.2 mmHg) affords 54.51 g (75.2%) of ethyl 2-(triphenylphosphoranylidene)propionate as a light-yellow solid, mp 156-158 °C.

Ethyl 2-(triphenylphosphoranylidene)propionate Upstream-Materialien And Downstream Produkte

Ethyl-2-(triphenylphosphoranyliden)propionat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5717-37-3, Ethyl 2-(triphenylphosphoranylidene)propionate Verwandte Suche:

Send Inquriy