Maprotilinhydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

Maprotiline hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.

• Beschreibung

  Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET; K_d = 11 nM) and is selective for NET over the serotonin (5-HT) and dopamine transporters (K_ds = 5,800 and 1,000 nM, respectively). Maprotiline also binds to the 5-HT receptor subtype 5-HT_2A (K_I = 51 nM), as well as histamine H₁, muscarinic acetylcholine, α₁-adrenergic, and dopamine D₂ receptors (K_ds = 2, 570, 90, and 350 nM, respectively). In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline (20 μM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide . Formulations containing maprotiline have been used in the treatment of depression and anxiety. This product is also available as an analytical reference material (Item Nos. 32702 | 33077).

• Chemische Eigenschaften

  Crystalline Solid

• Originator

  Maprotiline hydrochloride ,Mylan

• Verwenden

  Maprotiline Hydrochloride has also been shown to block apoptosis of spiny neurons and inhibit SLC6A2.

• Verwenden

  estrogen, with progesterone as oral contraceptive

• Verwenden

  Antidepressant

• Definition

  ChEBI: Maprotiline hydrochloride is a member of anthracenes.

• Manufacturing Process

  9-(3-Hydroxypropyl)anthracene was prepared by reduction of 3-(9-anthryl) propionic acid with LiAlH4. By action of thionylchloride and then methylamine the 9-(3-hydroxypropyl)anthracene was converted to 9-(3-methylaminopropyl) anthracene. By addition of ethylene to 9-(3-methylaminopropyl)anthracene (at 150°C, a pressure of ethylene 50 atm, 24 hours) was obtained 3-(9,10- dihydro-9,10-ethanoanthracene-9-yl)-N-methylpropylamine. Hydrochloride 3- (9,10-dihydro-9,10-ethanoanthracene-9-yl)-N-methylpropylamine may be prepared by action hydrochloric acid.

• Therapeutic Function

  Antidepressant

• Allgemeine Beschreibung

  Maprotiline hydrochloride, N-methyl-9,10-ethanoanthracene-9(10H)-propanamine hydrochloride (Ludiomil), is sometimesdescribed as a tetracyclic rather than a tricyclic antidepressant.The description is chemically accurate, but the compound,nonetheless, conforms to the overall TCA pharmacophore. Itis a dibenzobicyclooctadiene and can be viewed as a TCAwith an ethylene-bridged central ring. The compound is notstrongly anticholinergic and has stimulant properties. It canhave effects on the cardiovascular system. It is a SNERI.

• Biologische Aktivität

  Selective noradrenalin re-uptake inhibitor.

Maprotiline hydrochloride Upstream-Materialien And Downstream Produkte

Maprotilinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(200)Suppliers

10347-81-6, Maprotiline hydrochloride Verwandte Suche: