Ethylenbis[chlordimethylsilan]

Bezeichnung:Ethylenbis[chlordimethylsilan]

CAS-Nr13528-93-3

Englisch Name:1,2-Bis(chlorodimethylsilyl)ethane

CBNumberCB6154680

SummenformelC6H16Cl2Si2

Molgewicht215.27

MOL-Datei13528-93-3.mol

Synonyma

Ethylenbis[chlordimethylsilan]

Ethylenbis[chlordimethylsilan] physikalisch-chemischer Eigenschaften

Schmelzpunkt	35-38 °C (lit.)
Siedepunkt	198 °C/734 mmHg (lit.)
Dichte	0.99
Flammpunkt	155 °F
storage temp.	Inert atmosphere,Room Temperature
Aggregatzustand	Low Melting Solid
Farbe	Transparent
Wasserlöslichkeit	Reacts with water.
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
BRN	1920141
InChIKey	VGQOKOYKFDUPPJ-UHFFFAOYSA-N
CAS Datenbank	13528-93-3(CAS DataBase Reference)
EPA chemische Informationen	Silane, 1,2-ethanediylbis[chlorodimethyl- (13528-93-3)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34-10
S-Sätze:	26-28-36/37/39-45-16
RIDADR	UN 3261 8/PG 2
WGK Germany	3
F	10-21
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29319000

Gefahreninformationscode (GHS)

1,2-Bis(chlorodimethylsilyl)ethane Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R10:Entzündlich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S16:Von Zündquellen fernhalten - Nicht rauchen.
Chemische Eigenschaften
transparent low melting solid
Physikalische Eigenschaften
mp 36–41°C; bp 198°C/734 mmHg.
Verwenden
1,2-Bis(chlorodimethylsilyl)ethane is used as Protecting Reagent for Primary Amines. It is also used in Medicine field, electronics industry and polymer material.
Verwenden
1,2-Bis(chlorodimethylsilyl)ethane can be used as a reagent for the protection of primary amines as their tetramethyldisilylazacyclopentane or Stabase adducts; used in combination with zinc to form organozinc carbenoids; electrophilic silylating reagent.
Protection of Primary Amines.
Few protecting groups exist for the N,N-diprotection of primary amines. The tetramethyldisilylazacyclopentane or Stabase adduct (3) is particularly attractive for this purpose due to its ease of preparation, base stability and facile removal. This cyclic disilane is easily prepared (eq 1) from the commercially available title reagent (1).For primary amines with pKa values between 10 and 11, typical reaction conditions involve the treatment of a dichloromethane solution of the amine with (1) in the presence of two equivalents of triethylamine at room temperature. Subsequent workup with aqueous dihydrogen phosphate provides (3) in excellent yields.1 Stabase adducts are quite stable to strongly basic conditions such as n-butyllithium and s-butyllithium (at ?25°C), lithium diisopropylamide, and Grignard reagents making it a superb candidate for use in the alkylation of substrates bearing a primary amine. For example, protected amino acid derivatives are easily alkylated (eq 2).After formation of the lithium enolate of the protected ethyl glycinate (4) under standard conditions, exposure to various alkyl halides or aldehydes yields alkylation products such as (5).

1,2-Bis(chlorodimethylsilyl)ethane Upstream-Materialien And Downstream Produkte

Ethylenbis[chlordimethylsilan] Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

13528-93-3, 1,2-Bis(chlorodimethylsilyl)ethane Verwandte Suche:

Send Inquriy