1,1,2,2-Tetrachlorethan

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H411：Giftig für Wasserorganismen, mit langfristiger Wirkung.

• Sicherheit

  P262：Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

1,1,2,2-Tetrachloroethane Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.

• PHYSIKALISCHE GEFAHREN

  Die Dämpfe sind schwerer als Luft.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen und unter Einfluss von Luft, UV-Licht und Feuchtigkeit unter Bildung giftiger und ätzender Gase mit Chlorwasserstoff und Phosgen. Reagiert sehr heftig mit Alkalimetallen, starken Basen undvielen Metallpulvern unter Bildung giftiger und ätzender Gase. Greift Kunststoff und Gummi an.

• ARBEITSPLATZGRENZWERTE

  TLV: 1 ppm (als TWA); Hautresorption; Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
  MAK: 1 ppm, 7,0 mg/m? Spitzenbegrenzung: überschreitungsfaktor II(2); Hautresorption; Krebserzeugend Kategorie 3B; Schwangerschaft: Gruppe D (DFG 2006).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen, die Haut und die Atemwege. Möglich sind Auswirkungen auf Zentralnervensystem, Leber und Nieren mit nachfolgender Depression des Zentralnervensystems und Funktionsstörungen. Exposition kann zu Bewusstlosigkeit führen. Exposition kann zum Tod führen.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Die Flüssigkeit entfettet die Haut. Möglich sind Auswirkungen auf Zentralnervensystem und Leber mit nachfolgenden Funktionsstörungen.

• LECKAGE

  Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät. Belüftung. NICHT in die Umwelt gelangen lassen. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.

• R-Sätze Betriebsanweisung:

  R26/27:Sehr giftig beim Einatmen und bei Berührung mit der Haut.
  R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R59:Gefährlich für die Ozonschicht.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

• Aussehen Eigenschaften

  C2H2Cl4; (Acetylentetrachlorid)
  Farblose, sehr giftige Flüssigkeit mit chloroformartigem Geruch.

• Gefahren für Mensch und Umwelt

  Bei Kontakt mit Alkali- Erdalkalimetallen, Metallen in Pulverform, Natriumamid sind heftige Reaktionen oder Explosionen möglich.
  Tetrachlorethan gilt als der giftigste Vertreter der einfachen, als Lösemittel verwendeten aliphatischen Halogenkohlenwasserstoffe. Es wirkt sowohl akut als auch chronisch stark auf die Leber, daneben auch auf Nieren und ZNS. Es wird auch sehr leicht durch die Haut aufgenommen. Akute Einwirkungen höherer Dosen führt nach unterschiedlich ausgeprägten Schleimhautreizungen zu Übelkeit, Erbrechen, Schwindel und Narkose, in schweren Fällen zu Koma und Kreislaufkollaps. Leber- und Nierenschädigung. Auch Lungenödeme werden berichtet. Bei chronischer Einwirkung Ausbildung einer stark vergrößerten, tastbaren Leber, die sich zur fettigen Degeneration und zur Zirrhose entwickeln kann. Bei Geruchswahrnehmung kann eine Schädigung bereits eingetreten sein.

• Schutzmaßnahmen und Verhaltensregeln

  Arbeiten unter Abzug vornehmen. Dämpfe nicht einatmen.
  Latex- und Neoprenhandschuhe sind nicht beständig gegen 1,1,2,2-Tetrachlorethan. Schutzhandschuhe können nur als sehr kurzzeitiger Spritzschutz verwendet werden.
  Vorbeugender Hautschutz (Arbeitsschutzcreme) wird empfohlen.

• Verhalten im Gefahrfall

  Kleine Spritzer im Abzug verdampfen lassen. Bei Verschütten größerer Mengen: evtl. Bereich räumen, Hilfe herbeirufen. Mit flüssigkeitsbindendem Material, z.B. Rench-Rapid aufnehmen. Dämpfe nicht einatmen.
  CO2, Löschpulver, Wassersprühstrahl.

• Erste Hilfe

  Nach Hautkontakt: Sofort mit Seife und viel Wasser abwaschen.
  Nach Augenkontakt: Mit viel Wasser bei geöffnetem Lidspalt mindestens 15 Minuten spülen. Augenarzt!
  Nach Einatmen: Frischluft; ggf. Atemspende oder Gerätebeatmung. Arzt!
  Nach Verschlucken: Wasser trinken, kein Erbrechen herbeiführen. Sofort Arzt!
  Nach Kleidungskontakt: Kontaminierte Kleidung ausziehen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als Sondermüll (halogenhaltige Lösungsmittel) entsorgen.

• Beschreibung

  1,1,2,2-Tetrachloroethane (tetrachloroethane) is a volatile, synthetic, colorless to pale-yellow dense liquid with a pungent, chloroform-like odor that is soluble in water and most organic solvents. There are no known natural sources of tetrachloroethane. Tetrachloroethane is a chemical intermediate in the production of a variety of other common chemicals. In the past, the major use for tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. With the development of new processes for manufacturing chlorinated ethylenes and the availability of less-toxic solvents, the production of tetrachloroethane as a commercial endproduct in the United States and Canada has steadily declined since the late 1960s and the production ceased by the early 1990s. Although at one time it was used as an insecticide, fumigant, and weed killer, it presently is not registered for any of these purposes. Its registration as an insect repellent was canceled by the Environmental Protection Agency (EPA) in the late 1970s.

• Chemische Eigenschaften

  Tetrachloroethane is a heavy, volatile colorless to light yellow liquid. It has a sweetish, chloroform-like odor. The Odor Threshold is 0.5 ppm in water and 1.5 ppm in air.

• Chemische Eigenschaften

  colourless to light yellow liquid with a chloroform-like

• Physikalische Eigenschaften

  Colorless to pale yellow liquid with a sweet, chloroform-like odor. A detection odor threshold concentration of 50 mg/m³ (7.3 ppm_v) was experimentally determined by Dravnieks (1974).

• Verwenden

  Intermediate in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene; previously used as a solvent, insecticide and fumigant.

• Verwenden

  1,1,2,2-Tetrachloroethane, once used as a solvent for cleaning and extraction processes, is still used to some extent as a chemical intermediate. Present usage is quite limited because less toxic solvents are available.

• Verwenden

  Nonflammable solvent for fats, oils, waxes, resins, cellulose acetate, rubber, copal, phosphorus, sulfur. As solvent in certain types of Friedel-Crafts reactions or phthalic anhydride condensations. In the manufacture of paint, varnish, and rust removers. In soil sterilization and weed killer and insecticide formulations. In the determination of theobromine in cacao. As immersion fluid in crystallography. In the biological laboratory to produce pathological changes in gastrointestinal tract, liver, and kidneys. Intermediate in the manufacture of trichloroethylene and other chlorinated hydrocarbons having two carbon atoms.

• Definition

  ChEBI: A member of the class of chloroethanes that is ethane substituted by chloro groups at positions 1, 1, 2 and 2.

• Allgemeine Beschreibung

  Colorless to pale yellow liquid with a sweet odor. Sinks in water.

• Air & Water Reaktionen

  Insoluble in water.

• Reaktivität anzeigen

  1,1,2,2-Tetrachloroethane may be incompatible with strong oxidizing and reducing agents. Also may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Decomposed by heat and UV light, forming phosgene and HCl; reacts violently with finely dispersed metals [Handling Chemicals Safely 1980. p. 886].

• Hazard

  Toxic by ingestion, inhalation, skin absorption. Questionable carcinogen.

• Health Hazard

  Compound is a powerful narcotic and liver poison; may also cause changes in blood composition and neurological disturbances. Repeated exposure by inhalation can be fatal. Ingestion causes vomiting, diarrhea, severe mucosal injury, liver necrosis, cyanosis, unconsciousness, loss of reflexes, and death. Contact with eyes causes irritation and lachrymation. Can be absorbed through the skin and may produce severe skin lesions.

• Brandgefahr

  Special Hazards of Combustion Products: Irritating hydrogen chloride vapor may form in fire.

• Sicherheitsprofil

  Suspected carcinogen with experimental carcinogenic and tumorigenic data. Poison by inhalation, ingestion, and intraperitoneal routes. Moderately toxic by several other routes. Mutation data reported. Human central nervous system effects by ingestion and inhalation: general anesthesia, somnolence, hallucinations, and distorted perceptions. Considered the most toxic of the common chlorinated hydrocarbons. Considered to be a very severe industrial hazard and its use has been restricted or even forbidden in certain countries. It is not an inert solvent. Reacts violently with N2O4,2,4dinitrophenyl disulfide, and on contact with sodium or potassium. When heated in contact with solid potassium hydroxide, spontaneously flammable chloroor dichloroacetylene gas is evolved. Any water can cause appreciable hydrolysis, even at room temperature, and both hydrolysis and oxidation become comparatively rapid above 110'. When heated to decomposition it emits toxic fumes of Cl-. A strong irritant of eyes and mucous membranes. A concentration of 3 ppm produces a detectable odor, thus an initial produces a detectable odor, thus an initial warning effect. Its narcotic action is stronger than that of chloroform, but, because of its low volatility, narcosis is less severe and much less common in industrial poisoning than in the case of other chlorinated hydrocarbons. The toxic action of this material is chiefly on the liver, where it produces acute yellow atrophy and cirrhosis. Fatty degeneration of the kidneys and heart, hemorrhage into the lungs and serous membranes, and edema of the brain have also been found in fatal cases. Some reports indicate a toxic action on the central nervous system with changes in the brain and in the peripheral nerves. The effect on the blood is one of hemolysis with appearance of young cells in the circulation and a monocptosis. Due to its solvent action on the natural skin oils, dermatitis is not uncommon. The initial symptoms resulting from exposure to the vapor are lachrymation, salivation, and irritation of the nose and throat. Continued exposure to high concentrations results in restlessness, dizziness, nausea, vomiting, and narcosis. The latter, however, is rare in industry. More commonly, exposure is less severe and most complaints are vague and related to the digestive and nervous systems. The patient's symptoms gradually progress to a more serious illness with development of toxic jaundice, liver tenderness, etc., and possibly albuminuria and edema. With serious liver damage, the jaundice increases and toxic symptoms appear, with somnolence, delirium, convulsions, and coma usually precedmg death. See also ACETYLENE COMPOUNDS and CHLORIDES.

• mögliche Exposition

  Tetrachloroethane is used as an intermediate in the trichloroethylene production from acetylene and as a solvent; as a dry cleaning agent; as a fumigant; in cement; and in lacquers. It is used in the manufacture of artificial silk, artificial leather, and artificial pearls. Recently, its use as a solvent has declined due to replacement by less toxic compounds. It is also used in the estimation of water content in tobacco and many drugs, and as a solvent for chromium chloride impregnation of furs.

• Carcinogenicity

  The EPA has classified this material as “likely to be carcinogenic to humans” based on data from an oral cancer bioassay in male and female Osborne–Mendel rats and B6C3F1 mice. In mice, a significant increase in the incidence of hepatoceullar carcinomas in both genders was observed. Male Osborne–Mendel rats showed increased incidence of hepatocellular carcinomas, which is a rare tumor in this strain.
  The National Cancer Institute has included 1,1,2,2- tetrachloroethane in their bioassay series using rats and mice. Their summary states that the time-weighted average doses (by gavage) were 108 and 62 mg/kg/day for male rats, 76 and 43 mg/kg/day for female rats, and 282 and 142 mg/kg/day for all mice. There was a highly significant positive dose-related trend in the incidence of hepatocellular carcinoma in mice of both sexes. No statistically significant incidence of neoplastic lesions was observed in male or female rats. However, two hepatocellular carcinomas and one neoplastic nodule, which are rare tumors in the male Osborne–Mendel rat, were observed in high-dose males. Under the conditions of this bioassay, orally administered 1,1,2,2-tetrachloroethane was a liver carcinogen in B6C3Fl mice of both sexes.
  The proposed metabolic pathway involves the production of dichloroacetic acid, which was identified as the major urinary metabolite in treated mice. Other pathways involve formation of trichloroethylene via dehydrochlorination or tetrachloroethylene via oxidation. Free radicals may also be formed.
  From the NCI study, a oral slope factor (OSF) of 0.2 per mg/kg/day was developed by the EPA. No inhalation unit risk (IUR) was determined by the EPA because of absence of data from inhalation exposure.

• Environmental Fate

  Biological. Monodechlorination by microbes under laboratory conditions produced 1,1,2- trichloroethane (Smith and Dragun, 1984). In a static-culture-flask screening test, 1,1,2,2- tetrachloroethane (5 and 10 mg/L) was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum. No significant degradation was observed after 28 d of incubation (Tabak et al., 1981).
  Chemical/Physical. In an aqueous solution containing 0.100 M phosphate-buffered distilled water, 1,1,2,2-tetrachloroethane was abiotically transformed to 1,1,2-trichloroethane. This reaction was investigated within a temperature range of 30 to 95 °C at various pHs (5 to 9) (Cooper et al., 1987). Abiotic dehydrohalogenation of 1,1,2,2-tetrachloroethane yielded trichloroethylene (Vogel et al., 1987) and HCl (Kollig, 1993). The half-life for this reaction at 20 °C was reported to be 0.8 yr (Vogel et al., 1987). Under alkaline conditions, 1,1,2,2-tetrachloroethane dehydrohalogenated to trichloroethylene. The reported hydrolysis half-life of 1,1,2,2-tetrachloroethane in water at 25 °C and pH 7 is 146 d (Jeffers et al., 1989).
  The evaporation half-life of 1,1,2,2-tetrachloroethane (1 mg/L) from water at 25 °C using a shallow-pitch propeller stirrer at 200 rpm at an average depth of 6.5 cm was 55.2 min (Dilling, 1977).
  At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 11, 4.5, 1.9, and 0.8 mg/g, respectively (Dobbs and Cohen, 1980).

• Versand/Shipping

  UN1702 Tetrachloroethane or 1,1,2,2Tetrachloroe thane, Hazard Class: 6.1; Labels: 6.1Poisonous materials.

• läuterung methode

  Stir the ethane, on a steam-bath, with conc H2SO4 until a fresh portion of acid remains colourless. The organic phase is then separated, distilled in steam, dried (CaCl2 or K2CO3), and fractionally distilled in a vacuum. [Beilstein 1 IV 144.]

• Toxicity evaluation

  Metabolism of tetrachloroethane to reactive products plays a key role in its toxicity. Both nuclear and microsomal cytochrome P450 enzymes have been implicated in the metabolism of the compound, possibly releasing aldehydes, alkenes, acids, and free radicals that may react with biological tissues. Therefore, because of high metabolic activity of the liver, the formation of active metabolites is a likely mechanism for the toxicity tetrachloroethane. Hence, tetrachloroethane metabolism could result in the reductive formation of radical products, leading to the stimulation of lipid peroxidation resulting in hepatotoxic effects, as noted in carbon tetrachloride, a structurally related chlorinated alkane. Both dichloroacetic and trichloroacetic acids are known to cause proliferation of peroxisomes.
  The mechanism of neurological toxicity of tetrachloroethane has not been well characterized. Studies of similar compounds suggest that the parent compound itself may be the causative agent. This property allows interference with neural membrane function, bringing about central nervous system depression, behavioral changes, and anesthesia.
  The mechanisms by which tetrachloroethane produces carcinogenic effects are incompletely characterized. Tetrachloroethane has been shown to bind to DNA in the liver and several other organs in rats and mice, which may contribute to the carcinogenic process. Studies indicate that there may be initiating and promoting activities when tetrachloroethane is metabolized, possibly by cytochrome P450 enzymes producing urinary metabolites such as dichloroacetic acid, trichloroacetic acid, trichloroethylene, and tetrachloroethylene. Studies of chronic exposure of rats and mice to these specific metabolites revealed hepatic tumors in male and female mice. Although it is possible that the carcinogenicity of tetrachloroethane involves metabolism with these compounds, there is no direct evidence linking one or more metabolites to its carcinogenic effects. Tetrachloroethane may be metabolized to form free radicals, which can in turn covalently bind to tissues, including DNA.

• Inkompatibilitäten

  Violent reaction with chemically active metals; strong caustics; strong acids; especially fuming sulfuric acid. Degrades slowly when exposed to air. Attacks plastic and rubber.

• Filter für giftige stoffe

  The Initial Risk Screening Level (IRSL) for 1,1,2,2-tetrachloroethane is 0.02 μg/m3 based on an annual averaging time.

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

1,1,2,2-Tetrachloroethane Upstream-Materialien And Downstream Produkte

1,1,2,2-Tetrachlorethan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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