3-Amino-1-adamantanol

Bezeichnung:3-Amino-1-adamantanol

CAS-Nr702-82-9

Englisch Name:3-Amino-1-adamantanol

CBNumberCB5777891

SummenformelC10H17NO

Molgewicht167.25

MOL-Datei702-82-9.mol

3-Amino-1-adamantanol physikalisch-chemischer Eigenschaften

Schmelzpunkt	265 °C (dec.)(lit.)
Siedepunkt	266.8±23.0 °C(Predicted)
Dichte	1.252±0.06 g/cm3(Predicted)
Flammpunkt	230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	15.07±0.40(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	White to yellow
Wasserlöslichkeit	Soluble in organic solvents,insoluble in water.
InChI	InChI=1S/C10H17NO/c11-9-2-7-1-8(3-9)5-10(12,4-7)6-9/h7-8,12H,1-6,11H2
InChIKey	DWPIPTNBOVJYAD-UHFFFAOYSA-N
SMILES	C12(O)CC3CC(CC(N)(C3)C1)C2
CAS Datenbank	702-82-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29221990

Gefahreninformationscode (GHS)

3-Amino-1-adamantanol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
3-Amino-1-adamantanol is an important adamantane drug intermediate mainly used in the synthesis of inhibitors with antihyperglycaemic properties for the preparation of Vildagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor used in the treatment of type 2 diabetes.
Chemische Eigenschaften
White solid
Verwenden
3-Amino-1-hydroxyadamantane can be employed in the synthesis of inhibitors with antihyperglycemic properties.
Verwenden
As reagent, 3-Amino-1-hydroxyadamantane can be used in the preparation of Vildagliptin.
Verwenden
It is employed in the synthesis of inhibitors with antihyperglycemic properties. vil- dagliptin is synthesised from 3-Amino-1-adamantanol.
Synthese
A preparation method of 3-amino-1-adamantanol comprises the following steps: (1) adding amantadine or a salt thereof to sulfuric acid at 10-30 DEG C and adding a mixed acid dropwise to perform a nitration reaction to obtain a reaction liquid; (2) adding the reaction liquid to water and mixing the reaction liquid with water to obtain a mixed solution; (3) performing a hydroxylation reaction under the effect of alkaline to obtain the 3-amino-1-adamantanol. The preparation method employs the raw material, is easy to obtain, is simple in operations, is environmentally protective, is low in cost, and is high in yield, which is generally higher than 80%, maximally 90.1%.

3-Amino-1-adamantanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

702-82-9, 3-Amino-1-adamantanol Verwandte Suche:

Send Inquriy