3-Aminopropan-1-sulfonsaeure

Bezeichnung:3-Aminopropan-1-sulfonsaeure

CAS-Nr3687-18-1

Englisch Name:3-Amino-1-propanesulfonic acid

CBNumberCB2741107

SummenformelC3H9NO3S

Molgewicht139.17

MOL-Datei3687-18-1.mol

Synonyma

3-Aminopropan-1-sulfonsaeure

3-Aminopropan-1-sulfonsaeure physikalisch-chemischer Eigenschaften

Schmelzpunkt	293 °C (dec.)(lit.)
Dichte	1.202 (estimate)
Brechungsindex	1.5130 (estimate)
storage temp.	2-8°C
Löslichkeit	Water (Slightly)
Aggregatzustand	Crystalline Powder
pka	1.06±0.50(Predicted)
Farbe	White to slightly blue
LogP	-4.555
CAS Datenbank	3687-18-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	1
HS Code	29049090

Gefahreninformationscode (GHS)

3-Amino-1-propanesulfonic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.
Chemische Eigenschaften
White Powder
Verwenden
3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.
Definition
ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid.
Biologische Aktivität
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .

3-Aminopropan-1-sulfonsaeure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3687-18-1, 3-Amino-1-propanesulfonic acid Verwandte Suche:

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