3-Iodo-L-tyrosin

Bezeichnung:3-Iodo-L-tyrosin

CAS-Nr70-78-0

Englisch Name:3-IODO-L-TYROSINE

CBNumberCB5721061

SummenformelC9H10INO3

Molgewicht307.09

MOL-Datei70-78-0.mol

Synonyma

3-Iodo-L-tyrosin

3-Iodo-L-tyrosin physikalisch-chemischer Eigenschaften

Schmelzpunkt	210 °C (dec.)(lit.)
Dichte	1.7280 (estimate)
storage temp.	-20°C
Löslichkeit	dilute aqueous acid: soluble
Aggregatzustand	Solid
Siedepunkt	391.0±42.0 °C(Predicted)
pka	2.21±0.20(Predicted)
Farbe	White to off-white
Sensitive	Light Sensitive
Merck	14,5047
BRN	2941266
Stabilität	Hygroscopic
InChIKey	UQTZMGFTRHFAAM-ZETCQYMHSA-N
CAS Datenbank	70-78-0(CAS DataBase Reference)
EPA chemische Informationen	L-Tyrosine, 3-iodo- (70-78-0)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
F	8-10-23
HS Code	29225090

Gefahreninformationscode (GHS)

3-IODO-L-TYROSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White Solid
Verwenden
3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.
Verwenden
A novel flavoprotein responsible for iodide salvage in thyroid glands. A tyrosine hydroxylase inhibitor.
Verwenden
3-iodo-l-tyrosine is used in the inhibition of tyrosine hydroxylase. 3-iodo-L-tyrosine is used in the rapid induction of prolactin secretion.
Definition
ChEBI: The monoiodotyrosine that is L-tyrosine carrying an iodo-substituent at position C-3 of the benzyl group.
Allgemeine Beschreibung
Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).
Biochem/physiol Actions
3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.
läuterung methode
Likely impurities are tyrosine, diiodotyrosine and iodide. Crystallise it by dissolving it in concentrated ammonia (~200mg in ~20mL), evaporate to ~5mL and NH4Cl is added to pH4.5—5.0. After a few hours at 0o, the amino acid crystallises in needles. It is filtered off, washed with a little ice-cold H2O and dried in a vacuum. Alternatively dissolve it in dilute ammonia at room temperature, then add dilute acetic acid to pH 6. Store it at 0o. Recrystallisation of ~250mg from H2O (~5mL) removes any diiodotyrosine. It is an inhibitor of tyrosine hydroxylase with a Ki of ~500nM. [Harrington & Rivers Biochem J 38 320 1944, Rivers Chem & Ind (London) 21 1956, Beilstein 14 III 1562, 14 IV 1562.]

3-IODO-L-TYROSINE Upstream-Materialien And Downstream Produkte

3-Iodo-L-tyrosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

70-78-0, 3-IODO-L-TYROSINE Verwandte Suche:

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