3,5-Diiod-L-tyrosin

Bezeichnung:3,5-Diiod-L-tyrosin

CAS-Nr300-39-0

Englisch Name:3,5-Diiodo-L-tyrosine dihydrate

CBNumberCB5490149

SummenformelC9H9I2NO3

Molgewicht432.98

MOL-Datei300-39-0.mol

Synonyma

3,5-Diiod-L-tyrosin

3,5-Diiod-L-tyrosin physikalisch-chemischer Eigenschaften

Schmelzpunkt	200 °C (dec.)(lit.)
alpha	-20.7 º (c=2.5, 0.1N NaOH/H2O)
Siedepunkt	546.5°C (rough estimate)
Dichte	2.405±0.06 g/cm3(Predicted)
Brechungsindex	1.2 ° (C=5, 1mol/L HCl)
storage temp.	2-8°C
Löslichkeit	Aqueous Acid (Slightly), DMSO (Slightly)
pka	2.12(at 25℃)
Aggregatzustand	crystalline
Farbe	white
Wasserlöslichkeit	slightly soluble
Sensitive	Light Sensitive
CAS Datenbank	300-39-0(CAS DataBase Reference)
NIST chemische Informationen	3,5-Diiodo-l-tyrosine(300-39-0)
EPA chemische Informationen	L-Tyrosine, 3,5-diiodo- (300-39-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39-36/37-24/25
RIDADR	2811
WGK Germany	3
F	8
TSCA	Yes
HS Code	29225090

Gefahreninformationscode (GHS)

3,5-Diiodo-L-tyrosine dihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.
Chemische Eigenschaften
white to beige powder
Verwenden
3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.
Verwenden
It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.
Verwenden
3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.
Definition
ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.
Synthese
Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.
läuterung methode
It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]

3,5-Diiodo-L-tyrosine dihydrate Upstream-Materialien And Downstream Produkte

3,5-Diiod-L-tyrosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

300-39-0, 3,5-Diiodo-L-tyrosine dihydrate Verwandte Suche:

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