3,3',5-TRIIODOTHYROACETIC ACID Struktur

Tiratricol

Bezeichnung:Tiratricol

CAS-Nr51-24-1

Englisch Name:3,3',5-TRIIODOTHYROACETIC ACID

CBNumberCB8275848

SummenformelC14H9I3O4

Molgewicht621.93

MOL-Datei51-24-1.mol

Synonyma

Tiratricol

Tiratricol physikalisch-chemischer Eigenschaften

Schmelzpunkt	65°; mp 180-183°
Siedepunkt	531.6±50.0 °C(Predicted)
Dichte	2.466±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
Aggregatzustand	Solid
pka	4.02±0.10(Predicted)
Farbe	White to Pale Beige

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	36
WGK Germany	3
HS Code	2916.39.7900

Gefahreninformationscode (GHS)

3,3',5-TRIIODOTHYROACETIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White to Off-White Solid
Originator
Triacana,Ana,Italy,1972
Verwenden
3,3'',5-Triiodo Thyroacetic Acid (T3-Acetic Acid (USP)) is a thyroid hormone analogue. A potent Thyroxine impurity. Levothyroxine EP Impurity C.
Verwenden
thyroid agent
Manufacturing Process
Preparation of 3:5-diiodo-4-(4'-hydroxyphenoxy)phenylacetic acid (diacid): A solution of ethyl 3:5-diiodo-4-(4'-methoxyphenoxy)phenyl acetate (9.5 g) in acetic acid (60 ml) was heated under reflux with hydroiodic acid (SG 1.7, 50 ml) and red phosphorus (0.5 g) for 1 hour. The hot solution was filtered and the filtrate concentrated at 50°C and 15 mm of mercury to above 20 ml. The residue was treated with water (70 ml) containing a little sodium thiosulfate to decolorize the product. The solid was collected by filtration and purified by the method of Harington and Pitt-Rivers [Biochem. J. (1952), Vol. 50, page 438]. Yield 8.36 g (95%). After crystallization from 70% (v/v) acetic acid it melted at 219°C.
A solution of 438 mg of diac in methanol (20 ml) and ammonia solution (SG 0.88; 20 ml) was iodinated at 0°C with 1.8 ml 1 N iodine solution. The product was isolated in almost theoretical yield in a manner similar to that described for tetrac. After crystallization from 50% (v/v) methanol, triac was obtained as colorless needles which melted over the range 65°C to 90°C according to the rate of heating. The molten form resolidified at about 110°C and finally melted at 180°C to 181°C without decomposition. The compound, dried at 25°C/3 mm over silica gel, contains methanol of crystallization.
Therapeutic Function
Thyroid hormone

3,3',5-TRIIODOTHYROACETIC ACID Upstream-Materialien And Downstream Produkte

Tiratricol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

51-24-1, 3,3',5-TRIIODOTHYROACETIC ACID Verwandte Suche:

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