Oxamidsure

Bezeichnung:Oxamidsure

CAS-Nr471-47-6

Englisch Name:Oxamic acid

CBNumberCB5667743

SummenformelC2H3NO3

Molgewicht89.05

MOL-Datei471-47-6.mol

Synonyma

Oxamidsure

Oxamidsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	207-210 °C (dec.) (lit.)
Siedepunkt	165.08°C (rough estimate)
Dichte	1.6193 (rough estimate)
Brechungsindex	1.4264 (estimate)
storage temp.	2-8°C(protect from light)
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand	Crystalline Powder
pka	1.60±0.20(Predicted)
Farbe	White
Wasserlöslichkeit	Soluble in water 108 mg/mL.
Merck	14,6917
BRN	1743294
InChI	InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
InChIKey	SOWBFZRMHSNYGE-UHFFFAOYSA-N
SMILES	C(O)(=O)C(N)=O
CAS Datenbank	471-47-6(CAS DataBase Reference)
EPA chemische Informationen	Oxamic acid (471-47-6)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
TSCA	Yes
HS Code	29241990

Gefahreninformationscode (GHS)

Oxamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Oxamic acids also known to as oxalic acid monoamides have emerged as potent precursors for the generation of the carbamoyl radical. Oxamic acids can easily undergo decarboxylation through a single electron oxidation resulting in the generation of the reactive carbamoyl radical, which can then engage in diverse radical reactions or undergo a second single electron oxidation as originally unveiled by Minisci. Oxamic acids are thus versatile intermediates for the synthesis of nitrogen-containing organic molecules[1]. The oxidative decarboxylation of oxamic acids can be mediated through thermal, photochemical, electrochemical or photoelectrochemical means, generating carbamoyl radicals, which may further add to unsaturated systems to provide a broad range of important amides. Oxidative decarboxylation of oxamic acids also offers a straightforward entry for the preparation of urethanes, ureas, and thioureas.
Chemische Eigenschaften
Oxamic acid is a white, water-soluble solid. It is the monoamide ofoxalic acid. It can react with metal carbonates to form oxamate. Oxamic acid inhibits lactate dehydrogenase A.
Verwenden
Oxamic acid is an ozone oxidation product and is used in the synthesis of hydroxybenzimidazoles preparation as potential anti tumor agents targeting human lactate dehydrogenase A.This compound is suitable for lactate dehydrogenase (LDH) related research.
Definition
ChEBI: Oxamic acid is a dicarboxylic acid monoamide resulting from the formal condensation of one of the carboxy groups of oxalic acid with ammonia. It has a role as an Escherichia coli metabolite. It is a conjugate acid of an oxamate.
Application
Oxamic acid (OA) has applications in polymer chemistry. It increases the water solubility of certain polymers, including polyester,epoxide, and acrylic upon binding with them. Oxamic acid can be used as a reactant to prepare 6-phenanthridinecarboxamide by direct C-H carbamoylation reaction using ammonium persulfate in DMSO. It can also be used as an organic ligand to prepare functionalized metal oxide nanoparticles for various biological applications. OA along with p-aminobenzoic acid is used to functionalize Au nanoparticles for the development of a sensor to detect Fe3+ ions by the calorimetric method.
Einzelnachweise
[1] Ikechukwu Martin Ogbu . “Oxamic acids: useful precursors of carbamoyl radicals.” Chemical Communications 58 55 (2022): Pages 7593-7607.

Oxamic acid Upstream-Materialien And Downstream Produkte

Oxamidsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

471-47-6, Oxamic acid Verwandte Suche:

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