Natriumoxamat

Bezeichnung:Natriumoxamat

CAS-Nr565-73-1

Englisch Name:Oxamic acid sodium salt

CBNumberCB5262762

SummenformelC2H2NNaO3

Molgewicht111.03

MOL-Datei565-73-1.mol

Synonyma

Natriumoxamat

Natriumoxamat physikalisch-chemischer Eigenschaften

Schmelzpunkt	300 °C
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	PBS (pH 7.2): 10 mg/ml
Aggregatzustand	solid
Farbe	White to off-white
Wasserlöslichkeit	Soluble in water (10 mg/ml).
BRN	6538153
InChI	InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1
InChIKey	RQVZIJIQDCGIKI-UHFFFAOYSA-M
SMILES	C(=O)(N)C([O-])=O.[Na+]
CAS Datenbank	565-73-1(CAS DataBase Reference)
EPA chemische Informationen	Sodium oxamate (565-73-1)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
F	10
TSCA	Yes
HS Code	29241990

Oxamic acid sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Oxamic acid sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis. Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells.
Chemische Eigenschaften
white crystalline powder
Verwenden
Oxamic acid sodium salt is a lactate dehydrogenase (LDH) inhibitor. It is a suitable compound to investigate cancer cells that utilize the glycolytic pathway.This compound is suitable for lactate dehydrogenase (LDH) related research. It can be used as an inhibitor of gluconeogenesis useful for anticancer research.
Application
Sodium oxamate, an inhibitor of LDH-C4, prevented the AR induced by lysophosphatidylcholine (LPC) or NADH. Oxamic acid sodium salt is an lactic acid dehydrogenase. Sperm suspension and cytosol fraction activities were inhibited by sodium oxamate. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.
Biochem/physiol Actions
Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes.
in vitro
Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells. Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells. Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells. Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells. Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells.

Oxamic acid sodium salt Upstream-Materialien And Downstream Produkte

Natriumoxamat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

565-73-1, Oxamic acid sodium salt Verwandte Suche:

Send Inquriy