Pankreatin

Bezeichnung:Pankreatin

CAS-Nr8049-47-6

Englisch Name:Pancreatin

CBNumberCB5446742

SummenformelN/A

Molgewicht0

MOL-DateiMol file

Synonyma

Pankreatin

Pankreatin physikalisch-chemischer Eigenschaften

Dichte	1.4-1.52
Dampfdruck	0Pa at 25℃
storage temp.	-20°C
Löslichkeit	Soluble or partly soluble in water forming a slightly turbid solution; practically insoluble in ethanol (96%) and in ether .
Aggregatzustand	powder
Farbe	beige
Wasserlöslichkeit	Soluble in water. Insoluble in alcohol and ether.
Merck	13,7075
Stabilität	Stable. Incompatible with alcohols, strong acids.
LogP	-1.3 at 20℃ and pH5.7-5.8
EPA chemische Informationen	Pancreatin (8049-47-6)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-42-42/43
S-Sätze:	22-24-26-36/37-37/39
WGK Germany	1
RTECS-Nr.	RT9033000
F	3-10
TSCA	Yes
HS Code	35079090
Giftige Stoffe Daten	8049-47-6(Hazardous Substances Data)
Toxizität	LD50 orl-rat: >10 g/kg YACHDS 3,2427,75

Gefahreninformationscode (GHS)

Pancreatin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42:Sensibilisierung durch Einatmen möglich.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24:Berührung mit der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
cream powder
Chemische Eigenschaften
Pancreatin is a yellowish to cream-colored, amorphous powder with a strong odor. Slightly soluble in water. Hazard Identification (based on NFPA-704 M Rating System): Health 1, Flammability 1, Reactivity 0. Sparingly soluble in water.
History
The first observations and experimental demonstrations that pancreatin could be used to improve protein and fat digestion in animals and human patients are from the 19th century, soon after Claude Bernard had revealed the essential role of pancreatic secretion in the digestion of foods. In 1859, the dutch physician Joseph Alexander Fles showed that the daily intake of calf pancreas extract could restore the digestion of fat in a diabetic patient who suffered from diarrhea and had large amounts of fat in the stools. In 1890, Abelmann showed that the consumption of fresh pig pancreas could improve protein and fat digestion in dogs after surgical removal of the pancreas. This is considered as the first experimental demonstration of enzyme replacement[1].
Verwenden
Pancreatin from porcine pancreas has been used:
- for a study to assess the treatment of steatorrhea by lipase supplementation therapy
- for a study to investigate treatment options for pancreatic diabetes in patients experiencing the decompensated stage of chronic pancreatitis
- to safely and effectively remove formalin-fixed tissues from arterial grafts without causing structural damage and loss in fiber integrity
- to assess cleavage by digestive enzymes.
- for in vitro digestibility analysis and to test the sensitivities of cellulolytic bacteria inhibitors.
- along with amyloglucosidase for the in vitro digestion of starch in food samples.
Verwenden
Hydrolyzes starch into dextrins and sugar Pancreatin from porcine pancreas is used in the treatment of steatorrhea by lipase supplementation therapy and for pancreatic diabetes. It is also used in the removal of formalin-fixed tissues from arterial grafts without causing damage in fiber integrity. Further, it finds uses in contact lenses. In addition to this, it hydrolyzes starch into dextrins and sugar. It is also used to treat conditions responsible for deficiency in pancreatic secretions, such as surgical pancreatectomy, pancreatitis and cystic fibrosis.
Verwenden
Enzyme (digestant adjunct).
Trademarks
Panteric (Parke-Davis).
Biologische Funktion
Pancreatin is a supplement that can result in decreased food intake. It is used for digestion, and absorption of food. Your pancreas secretes about one and one half quarts of pancreatic juice daily into the small intestine.
Allgemeine Beschreibung
Pancreatin (Panteric) is a substance obtained from the fresh pancreas of the hog or the ox and contains a mixture of enzymes, principally pancreatic amylase (amylopsin), protease, and pancreatic lipase (steapsin). It converts not less than 25 times its weight of USP Potato Starch Reference Standard into soluble carbohydrates and not less than 25 times its weight of casein into proteoses. It acts best in neutral or faintly alkaline media, and excessive acid or alkali renders it inert. Pancreatin can be prepared by extracting the fresh gland with 25% alcohol or with water and subsequently precipitating with alcohol. Besides the enzymes mentioned, it contains some trypsinogen, which can be activated by intestinal enterokinase; chymotrypsinogen, which is converted by trypsin to chymotrypsin; and carboxypeptidase.
Pancreatin is used largely for predigestion of food and for the preparation of hydrolysates. The value of its enzymes orally must be very small because they are digested by pepsin and acid in the stomach, although some of them may escape into the intestines without change. Even if they are protected by enteric coatings, it is doubtful they could be of great assistance in digestion.
Biochem/physiol Actions
Due to the enzymatic components such as trypsin, amylase and lipase, pancreatin hydrolyzes proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40?°C, will digest not less than 25 times its weight of casein in 60 minutes at pH7.5 at 40?°C and will release not less than 2 microequivalents of acid per min per mg pancreatin from olive oil at pH9.0 at 37?°C.
Sicherheitsprofil
Moderately toxic by subcutaneous and intraperitoneal routes.
mögliche Exposition
It is an enzyme found in the pancreas and is used in medicines and in treating leather and textiles.
Stoffwechsel
Pharmacokinetic data are not available as the enzymes act locally in the gastrointestinal tract. After exerting their action, the enzymes are digested themselves in the intestine.
Inkompatibilitäten
Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols.
Einzelnachweise
[1] Amal Salhi . “Characterization of all the lipolytic activities in pancreatin and comparison with porcine and human pancreatic juices.” Biochimie 169 (2020): Pages 106-120.

Pancreatin Upstream-Materialien And Downstream Produkte

Pankreatin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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