Trichlormethiazid

Bezeichnung:Trichlormethiazid

CAS-Nr133-67-5

Englisch Name:Trichlormethiazide

CBNumberCB5407444

SummenformelC8H8Cl3N3O4S2

Molgewicht380.66

MOL-Datei133-67-5.mol

Synonyma

Trichlormethiazid

Trichlormethiazid physikalisch-chemischer Eigenschaften

Schmelzpunkt	248-250℃
Siedepunkt	631.3±65.0 °C(Predicted)
Dichte	1.748
Brechungsindex	1.6000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	pKa 6.9(acetone/H2O) (Uncertain)
Farbe	White to Off-White
Merck	14,9624
CAS Datenbank	133-67-5(CAS DataBase Reference)
EPA chemische Informationen	Trichlormethiazide (133-67-5)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	42/43
S-Sätze:	36
WGK Germany	2
RTECS-Nr.	DK8925000
HS Code	2935904000
Giftige Stoffe Daten	133-67-5(Hazardous Substances Data)
Toxizität	LD50 orally in rats: >20000 mg/kg (Goldenthal)

Gefahreninformationscode (GHS)

Trichlormethiazide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.
Originator
Naqua,Schering,US,1960
Verwenden
Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).
Verwenden
diuretic, antihypertensive
Verwenden
Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.
Definition
ChEBI: Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.
Manufacturing Process
A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.
Therapeutic Function
Diuretic

Trichlormethiazide Upstream-Materialien And Downstream Produkte

Trichlormethiazid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

133-67-5, Trichlormethiazide Verwandte Suche:

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