Tetracyclinhydrochlorid

Bezeichnung:Tetracyclinhydrochlorid

CAS-Nr64-75-5

Englisch Name:Tetracycline hydrochloride

CBNumberCB1704886

SummenformelC22H25ClN2O8

Molgewicht480.9

MOL-Datei64-75-5.mol

Synonyma

Tetracyclinhydrochlorid

Tetracyclinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	220-223 °C(lit.)
alpha	-252 º (c=0.5, H2O)
Brechungsindex	-253 ° (C=0.5, 0.1mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	H₂O: 10 mg/mL as a stock solution. Stock solutions should be filtered sterilized and stored at −20°C. Stable at 37°C for 4 days.
Aggregatzustand	powder
Farbe	faint yellow to yellow
PH	pH(10g/l, 25℃) : 1.8～3.0
Optische Aktivität	[α]/D -255 to 240° (Specific rotation )
Wasserlöslichkeit	50 g/L
Sensitive	Air & Light Sensitive
Merck	14,9196
BRN	3844873
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	XMEVHPAGJVLHIG-FMZCEJRJSA-N
CAS Datenbank	64-75-5(CAS DataBase Reference)
EPA chemische Informationen	Tetracycline hydrochloride (64-75-5)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-20/21/22
S-Sätze:	26-36
RIDADR	UN 3077 9 / PGIII
WGK Germany	2
RTECS-Nr.	QI9100000
F	8-10-23
TSCA	Yes
HazardClass	3
HS Code	29413000
Toxizität	LD50 orally in rats: 6443 mg/kg (Goldenthal)

Gefahreninformationscode (GHS)

Tetracycline hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Tetracycline is a broad-spectrum antibiotic that prevents bacterial growth by inhibiting protein synthesis. It binds to a single site in the 30S ribosomal subunit which prevents attachment of aminoacyl tRNA to the ribosomal acceptor site. It is used in cell biology as a selective agent in cell culture systems. Tetracycline is toxic to prokaryotic and eukaryotic cells and selects for cells harboring the bacterial tetR gene, which are resistant to the antibiotic.
Chemische Eigenschaften
Yellow crystalline powder
Verwenden
Tetracycline hydrochloride is a salt prepared from tetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Tetracycline hydrochloride has broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-unit,s blocking protein synthesis.
Verwenden
Antibiotic substance produced by Streptomyces spp. Antiamebic; antibacterial; antirickettsial.
Verwenden
Tetracycline hydrochloride is used to induce apoptosis in osteoclasts. It is used to treat acne and other skin infections, respiratory tract infections like pneumonia, genital, urinary infections, leptospirosis, helicobacter pylori, taxoplasmosis, mycoplasma, psittacosis for dog and cats. It also works more effectively in animals that have tick-borne infections. It is also useful in cell culture applications.
Allgemeine Beschreibung
Crystals or fine bright yellow powder. pH of 2% aqueous solution: 2.1 - 2.3.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
Tetracycline hydrochloride is acidic. Reacts with strong oxidizing agents .
Brandgefahr
Flash point data concerning Tetracycline hydrochloride are not available, however, Tetracycline hydrochloride is probably combustible.
Biochem/physiol Actions
Primary Targetbinding of aminoacyl tRNA to the A-site of ribosomes
Sicherheitsprofil
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects: change in taste function. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also TETRACYCLINE.
Veterinary Drugs and Treatments
While tetracycline still is used as an antimicrobial, most small animal clinicians prefer doxycycline and large animal clinicians prefer oxytetracycline when a tetracycline is indicated to treat susceptible infections. The most common use of tetracycline HCl today is in combination with niacinamide for the treatment of certain immune- mediated skin conditions in dogs, such as pemphigus.
läuterung methode
The hydrochloride is recrystallised from MeOH/n-BuOH or n-BuOH/HCl. It is insoluble in Et2O and pet ether. It has UV max at 270 and 366nm in MeOH. [Gottstein et al. J Am Chem Soc 81 1198 1959, Conover et al. J Am Chem Soc 84 3222 1962, Stephen et al. J Am Chem Soc 78 4155 1956, Beilstein 14 IV 2627.]

Tetracycline hydrochloride Upstream-Materialien And Downstream Produkte

Tetracyclinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

64-75-5, Tetracycline hydrochloride Verwandte Suche:

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