Probucol Produkt Beschreibung

Probucol Struktur
23288-49-5
  • CAS-Nr.23288-49-5
  • Bezeichnung:Probucol
  • Englisch Name:Probucol
  • Synonyma:Probucol
    dh581;bisbid;Lorelc;LipoMal;lorelco;PROBUCOL;lurselle;PHENBUTOL;Sinlestal;biphenabid
  • CBNumber:CB5244083
  • Summenformel:C31H48O2S2
  • Molgewicht:516.84
  • MOL-Datei:23288-49-5.mol
Probucol physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :126-128°C
  • Siedepunkt: :571.58°C (rough estimate)
  • Dichte :1.0008 (rough estimate)
  • Brechungsindex :1.5341 (estimate)
  • storage temp.  :Desiccate at +4°C
  • Aggregatzustand :neat
  • Merck  :14,7755
  • InChIKey :FYPMFJGVHOHGLL-UHFFFAOYSA-N
  • CAS Datenbank :23288-49-5(CAS DataBase Reference)
Sicherheit
  • WGK Germany  :2
  • RTECS-Nr. :AL3705000
  • HS Code  :2930902000

Probucol Chemische Eigenschaften,Einsatz,Produktion Methoden

  • Chemische Eigenschaften White Solid
  • Verwenden antihyperlipidemic
  • Verwenden Probucol is an antilipemic.
  • Verwenden anti-hyperlipoproteinemic
  • Verwenden An antioxidant, anti-inflammatory, and hypocholesterolemic agent which inhibits atherogenesis in murine models.
  • Definition ChEBI: A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high l vels of cholesterol in blood.
  • Trademarks Lorelco (Sanofi Aventis).
  • Biologische Funktion Probucol (Lorelco) is a hypocholesterolemic drug with few side effects that modestly (15–30%) decreases elevated plasma LDL cholesterol levels. The marginal LDL-lowering action plus reports that it can lower HDL cholesterol resulted in its discontinuation as a hypocholesterolemic drug. However, it still may reduce the risk of CHD because it is a powerful antioxidant.
    The oxidation hypothesis of atherosclerosis states that oxidation of lipids in LDL is required for LDL uptake by macrophages and smooth muscle cells in the intima of arteries, leading to their transformation to foam cells, an early event in atherogenesis. A recent clinical trial reported that use of probucol decreased the rate of restenosis of coronary arteries by 50% in patients who underwent angioplasty. Fluvastatin also has potent antioxidant properties that may contribute to its antiatherosclerotic effects.These findings suggest that reducing high plasma lipids may not be the only approach to retarding the progression of atherosclerosis and decreasing the risk of coronary heart disease.
  • Allgemeine Beschreibung Probucol, 4,4' -[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol], DH-581(Lorelco), is a chemical agent that was developed for the plasticsand rubber industry in the 1960s. The probucol moleculehas two tertiary butylphenol groups linked by a dithiopropylidenebridge, giving it a high lipophilic character with strongantioxidant properties. In humans, it causes reduction of bothliver and serum cholesterol levels, but it does not alter plasmatriglycerides. It reduces LDL and (to a lesser extent) HDLlevels by a unique mechanism that is still not clearly delineated.The reduction of HDL may be caused by the ability ofprobucol to inhibit the synthesis of apoprotein A-1, a majorprotein component of HDL. It is effective at reducing levelsof LDL and is used in hyperlipoproteinemias characterized byelevated LDL levels.
  • Biologische Aktivität Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.
Probucol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Probucol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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23288-49-5, Probucol Verwandte Suche:
  • PROBUCOL
  • 4,4’-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl)-pheno
  • biphenabid
  • bisbid
  • bisphenabid
  • Probucol (200 mg)
  • Probucol-[13C3]
  • Bis(3,5-di-tert-butyl-4-hydroxyphenyl) Mercaptole Acetone
  • LipoMal
  • Lorelc
  • Probucol Tablets
  • dh581
  • 4,4'-ISOPROPYLIDINEDITHIO-BIS-(2,6-DI-TERT-BUTYL)PHENOL
  • 4-({1-[(4-hydroxy-3,5-di-t-butylphenyl)thio]-1-methylethyl}thio)-2,6-di-t-butylphenol
  • ACETONE BIS(3,5-DI-TERT-BUTYL-4HYDROXYPHENYL) MERCAPTOLE
  • 2,2-propdiyl-bis(4-thio-2,6-di-tert-butylphenol)
  • lorelco
  • lurselle
  • AURORA KA-671
  • CBI-BB ZERO/001429
  • PROBUCOL,USP
  • PHENBUTOL
  • bis (2, 6 - di - tert - butyl - phenol), 4, 4' - Isopropylidenedithio
  • 4,4’-[(1-Methylethylidene)bis(thio)]bis[2,6-dis(1,1-dimethylethyl)phenol]
  • DlH-581:Sinlestal
  • 4,4'-(Isopropylidenedithio)bis(2,6-tert-butylphenol)
  • 4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol]
  • 2,2-Bis(3,5-di-tert-butyl-4-hydroxyphenylthio)propane
  • 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]
  • Sinlestal
  • Quality Standard
  • 23288-49-5
  • C31H48O2S2
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