Ciprofloxacin hydrochloride hydrate

Bezeichnung:Ciprofloxacin hydrochloride hydrate

CAS-Nr86393-32-0

Englisch Name:Ciprofloxacin hydrochloride hydrate

CBNumberCB4740508

SummenformelC17H21ClFN3O4

Molgewicht385.82

MOL-Datei86393-32-0.mol

Ciprofloxacin hydrochloride hydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	318-320 °C
RTECS-Nr.	VB1993800
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol, practically insoluble in acetone, in ethyl acetate and in methylene chloride.
Farbe	White to Light yellow
PH	pH (25g/l, 25℃) 3.0～4.5
Wasserlöslichkeit	Soluble in water (35mg/ml).
Merck	14,2314
InChIKey	DIOIOSKKIYDRIQ-UHFFFAOYSA-N
CAS Datenbank	86393-32-0(CAS DataBase Reference)

Sicherheit

WGK Germany	3
HazardClass	IRRITANT
HS Code	2933595960

Gefahreninformationscode (GHS)

Ciprofloxacin hydrochloride hydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Pale yellow, crystalline, slightly hygroscopic powder.
Verwenden
Fluoroquinolone antibacterial.
Verwenden
Ciprofloxacin hydrochloride has been suggested as a treatment for a wide range of infections caused by susceptible organisms including infections of urinary, respiratory, and gastrointestinal tracts, gonorrhoea and septicaemia. Nalidixic acid analogue.
Application
Ciprofloxacin hydrochloride hydrate is a broad-spectrum antibiotic that inhibits bacterial DNA gyrase and blocks DNA synthesis and replication, resulting in bacterial death. It has strong antibacterial activity against Escherichia coli, Klebsiella and other Enterobacteriaceae; the antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae is better than norfloxacin and pefloxacin.
Definition
ChEBI: The monohydrate form of ciprofloxacin monohydrochloride.
Trademarks
Ciloxan (Alcon); Cipro (Bayer); Proquin (Esprit).
Allgemeine Beschreibung
Ciprofloxacin HCl is a fluoroquinolone antibiotic agent, which shows a broad spectrum of antibacterial activity against gram positive and gram negative bacteria.
in vitro
Ciprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC 90 of 0.03 μg/mL.
in vivo
Ciprofloxacin (hydrochloride monohydrate) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (hydrochloride monohydrate) (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (hydrochloride monohydrate). Intraperitoneal Ciprofloxacin (hydrochloride monohydrate) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.

Ciprofloxacin hydrochloride hydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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