4-Hydroxy-3-(3-(4'-brom-4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)cumarin

Bezeichnung:4-Hydroxy-3-(3-(4'-brom-4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)cumarin

CAS-Nr56073-10-0

Englisch Name:Brodifacoum

CBNumberCB4682121

SummenformelC31H23BrO3

Molgewicht523.42

MOL-Datei56073-10-0.mol

Synonyma

4-Hydroxy-3-(3-(4'-brom-4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)cumarin

4-Hydroxy-3-(3-(4'-brom-4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)cumarin physikalisch-chemischer Eigenschaften

Schmelzpunkt	228-230°
Siedepunkt	679.0±55.0 °C(Predicted)
Dichte	1.2940 (rough estimate)
Dampfdruck	41 x l0^-6 Pa (20 °C)
Brechungsindex	1.4620 (estimate)
storage temp.	0-6°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly)
pka	5.0 (weak acid, est.)
Wasserlöslichkeit	0.24 mg l^-1 (20 °C)
Merck	13,1363
BRN	8171403
CAS Datenbank	56073-10-0(CAS DataBase Reference)
EPA chemische Informationen	Brodifacoum (56073-10-0)

Sicherheit

Kennzeichnung gefährlicher	T+;N,N,T+
R-Sätze:	27/28-48/24/25-50/53
S-Sätze:	1/2-36/37-45-60-61
RIDADR	UN 2811
WGK Germany	3
RTECS-Nr.	GN4934750
HazardClass	6.1(a)
PackingGroup	I
Giftige Stoffe Daten	56073-10-0(Hazardous Substances Data)
Toxizität	LD50 orally in male, female field rats: 0.16, 0.18 mg/kg (Yuet-Ming)

Gefahreninformationscode (GHS)

Brodifacoum Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R27/28:Sehr giftig bei Berührung mit der Haut und beim Verschlucken.
R48/24/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Berührung mit der Haut und durch Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S1/2:Unter Verschluss und für Kinder unzugänglich aufbewahren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Brodifacoum is a 4-hydroxycoumarin anticoagulant that acts as a vitamin K antagonist. It was registered as a pesticide in 1979 in the United States although in 2008 it was made a restricted use pesticide by the Environmental Protection Agency. This means it can only be used by certified pesticide applicators; however, the makers of D-Con which contains 0.005% brodifacoum by weight have challenged this and brodifacoum is currently available in D-Con and in various other pesticide products for the eradication of mice and rats although it is also used on larger mammals such as possums. Brodifacoum currently remains available to the general public.
Chemische Eigenschaften
White Solid
Verwenden
Brodifacoum is used to control rodents in and around buildings.
Verwenden
Rodenticide.
Verwenden
Brodifacoum is a highly lethal vitamin K antagonist anticoagulant poison. In recent years, Broadifacoum, has become one of the world's most widely used pesticides.
Definition
ChEBI: Brodifacoum is a member of benzenes, a ring assembly and a member of naphthalenes.
Hazard
Poison, anticoagulant.
Environmental Fate
Brodifacoum, like other hydroxycoumarins, interferes with the production of vitamin K–dependent coagulation factors. Vitamin K is a cofactor for the carboxylation of specific glutamic acid groups in coagulation factors II (prothrombin), VII, IX, and X. During this step, vitamin K is oxidized to vitamin K 2,3-epoxide. The regeneration of vitamin K by vitamin K 2,3-epoxide reductase is prevented by brodifacoum. As a result, dysfunctional decarboxy-coagulation factors are produced and coagulation is impaired. Brodifacoum is over 100 times more potent than warfarin on a molar basis in rats.
Stoffwechselwegen
The fate of brodifacoum in soils and plants has not been studied in detail because the compound is usually applied as a pelleted bait or in a wax block. This limits its dissipation in the environment. Studies in animals have been conducted as part of the assessment of safety and to investigate mode of action.
Degradation
Brodifacoum is a stable compound; no detectable degradation occurs at 50 °C or in direct sunlight over 30 days, though it is liable to some photodecomposition in solution.
Toxicity evaluation
Brodifacoum has a very low solubility in water and typically enters water through erosion where it is then found in the sediment. Brodifacoum concentrations are typically not measurable in water systems.
Products that contain brodifacoum as pesticide can remain toxic for a long period of time in the environment. The rate of decay of brodifacoum depends upon the amount of rainfall. As the product that contains brodifacoum degrades over time, the brodifacoum is absorbed into the soil. Soil bacteria degrade brodifacoum over weeks to months although soil type, temperature, and the presence of microorganisms that will degrade brodifacoum all influence the time it takes to degrade.

Brodifacoum Upstream-Materialien And Downstream Produkte

56073-10-0, Brodifacoum Verwandte Suche:

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