Phosphortribromid

Bezeichnung:Phosphortribromid

CAS-Nr7789-60-8

Englisch Name:Phosphorus tribromide

CBNumberCB8372891

SummenformelBr3P

Molgewicht270.69

MOL-Datei7789-60-8.mol

Synonyma

Phosphortribromid

Phosphortribromid physikalisch-chemischer Eigenschaften

Schmelzpunkt	-41.5 °C (lit.)
Siedepunkt	175 °C (lit.)
Dichte	2.88 g/mL at 20 °C (lit.)
Dampfdichte	9.3 (vs air)
Dampfdruck	0.27 psi ( 54 °C)
Brechungsindex	n20/D 1.697(lit.)
Flammpunkt	172.9°C
storage temp.	Store below +30°C.
Löslichkeit	soluble in Ether,Acetone,Chloroform
Aggregatzustand	Liquid
Wichte	2.88
Farbe	Clear to slightly hazy colorless to yellow or light brown
Geruch (Odor)	Irritating odour
Wasserlöslichkeit	reacts
FreezingPoint	-40℃
Sensitive	Moisture Sensitive
Merck	14,7357
BRN	3903060
Dielectric constant	3.9（20℃）
Stabilität	Stable, but reacts violently with water. Incompatible with moisture, strong bases, strong oxidizing agents, reactive metals, acids, alcohols.
InChIKey	IPNPIHIZVLFAFP-UHFFFAOYSA-N
LogP	2.394 (est)
CAS Datenbank	7789-60-8(CAS DataBase Reference)
NIST chemische Informationen	Phosphorus tribromide(7789-60-8)
EPA chemische Informationen	Phosphorus tribromide (7789-60-8)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34-37-40-14-67
S-Sätze:	26-45-36/37-36/37/39
RIDADR	UN 3264 8/PG 2
WGK Germany	2
RTECS-Nr.	TH4460000
F	21
TSCA	Yes
HS Code	2812 90 00
HazardClass	8
PackingGroup	II
Giftige Stoffe Daten	7789-60-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Phosphorus tribromide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R37:Reizt die Atmungsorgane.
R40:Verdacht auf krebserzeugende Wirkung.
R14:Reagiert heftig mit Wasser.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Phosphorus tribromide is a colourless liquid(possibly hazy) with the formula PBr3. It fumes in air due to hydrolysis and has a penetrating odour. It is widely used in the laboratory for the conversion of alcohols toalkyl bromides.
Phosphorus tribromide (PBr3) is commonly used in Hell-Volhard-Zelinsky halogenation for the α-bromination of carboxylic acids to form the corresponding acyl bromide. It is also useful for the conversion of primary and secondary alcohols to alkyl bromides.
Verwenden
Phosphorus tribromide is used mainly for the conversion of alcohols to alkyl bromides and it is used in tests for skin corrosivity. It is used for alkene preparation and it act as a lewis base and a lewis acid. Phosphorus tribromide is used in the manufacture of pharmaceuticals such as alprazolam, methohexital and fenoprofen.
Phosphorus tribromide may be used as a reagent:
In a novel protocol for synthesizing 7-ethoxy-1-(p-ethylphenoxy)-3,7-dimethyl-2-octene, a synthetic juvenile hormone mimic of trans,trans,cis-10,11-epoxy-7-ethyl-3,11-dimethyltrideca-2,6-dienoate.
To synthesize 1,2,3-diazaphosphinane, 1,2,3-thiazaphosphinine and 1,2-azaphosphole bearing a chromone ring.
To synthesize 1-Bromoundec-1-ene from 10-undecen-1-ol.
Verwenden
Phosphorus(III) bromide is used mainly for the conversion of alcohols to alkyl bromides and it is used in tests for skin corrosivity. It is used for alkene preparation and it act as a lewis base and a lewis acid. It is used as a catalyst for the alpha-bromination of carboxylic acids and used as intermediates in hell-volhard-zelinsky halogenation. Phosphorus tribromide is used in the manufacture of pharmaceuticals such as alprazolam, methohexital and fenoprofen. It is also used as a fire suppression agent.
synthetische
Phosphorus tribromide, PBr3, is most conveniently prepared by reaction between liquid bromine and a solution of white phosphorus in PBr3. In most of its reactions, the tribromide resembles the trichloride although the former has been much less studied and in some cases the products seem to be more complex.
Reaktionen
Silyl phosphites such as (EtO)2POSiMe3 and (Et3SiO)3P are known. The latter compound can be prepared in 30% yield by reacting phosphorus tribromide with an organosilane in the presence of zinc chloride. Esters of the former type can be made by reaction.
3Et3SiO+PBr3–-(Et3SiO)3+3RBr
Et3SiONa+(EtO)2PCl–-(EtO)2POSiEt3+NaCl)
Allgemeine Beschreibung
A colorless fuming liquid with a pungent odor. Corrosive to metals and tissue. Boiling point 347°F (175°C). Freezing point -40°F (-40°C).
Air & Water Reaktionen
Fumes in air. Decomposed by water to form phosphoric acid and hydrobromic acid. Reaction with warm water is very rapid and may be violent [Mellor v.8. 1032 1940].
Reaktivität anzeigen
Phosphorus tribromide reacts with oxidizing agents to generate heat and products that may be flammable, combustible, or otherwise reactive; the reactions may be violent. Forms complexes with potassium or sodium metal that explode when shocked. Drop wise addition to 3-phenylpropanol caused an explosion when stirring of the mixture was discontinued [Chem. Brit., 1974, 10, 101-102].
Health Hazard
Inhalation causes severe irritation of nose, throat, and lungs. Ingestion causes burns of mouth and stomach. Contact with eyes or skin causes severe burns.
Sicherheitsprofil
Probably highly toxic. A corrosive irritant to the eyes, skin, and mucous membranes. Wdl react with water, steam, or acids to produce heat, toxic and corrosive fumes. Violent reaction or ignition with calcium hydroxide + sodium carbonate, phenylpropanol, sulfuric acid, oleum, fluorosulfuric acid, chlorosulfuric acid, 1,1,1 -tris(hydroxymethyl)methane, water, potassium, sodium, RuO4. When heated to decomposition it emits very toxic fumes of Brand POx. See also PHOSPHIDES and BROMIDES.
läuterung methode
It is decomposed by moisture, it should be kept dry and is corrosive. Purify it by distillation through an efficient fractionating column [see Whitmore & Lux J Am Chem Soc 54 3451] in a slow stream of dry N2, i.e. under strictly dry conditions. [Gay & Maxson Inorg Synth II 147 1946, Org Synth Col Vol II 358 1943.] Dissolve it in CCl4, dry it over CaCl2, filter and distil it. Store it in sealed ampoules under N2 and keep it away from light. HARMFUL VAPOURS.

Phosphorus tribromide Upstream-Materialien And Downstream Produkte

Phosphortribromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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