2-Bromo-7-hydroxynaphthalene

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H318：Verursacht schwere Augenschäden.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-Bromo-7-hydroxynaphthalene Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White powder

• Synthese

  

  582-17-2

  

  116230-30-9

  The general procedure for the synthesis of 7-bromo-2-naphthol from 2,7-dihydroxynaphthalene was as follows: 1. Preparation of 2-bromo-7-methoxynaphthalene: Triphenylphosphine (89.7 g, 0.342 mol) and acetonitrile (350 mL) were added to a 1 L flask under nitrogen protection and the mixture was cooled to 10 °C. Bromine (17.6 mL, 0.342 mol) was added slowly and dropwise over 10 min. After removing the cooling bath, 2,7-dihydroxynaphthalene (50.0 g, 0.312 mol) was added and rinsed with 350 mL of acetonitrile. The resulting yellow-brown mixture was heated to reflux for 3 hours. Subsequently, the acetonitrile was removed by distillation under reduced pressure, taking about 2 hours to give an off-white solid. 2. Preparation of 7-bromo-2-naphthol: The above solid was heated to 280°C within 30 minutes to form a black liquid. The liquid was continued to be heated to 310°C within 20 minutes and maintained at this temperature for 15 minutes until gas release ceased. After the black mixture was cooled to room temperature, 34.5 g of the intermediate title compound was obtained by chromatographic separation as an off-white solid with HPLC purity of 87% (43% yield).

• Einzelnachweise

  [1] Journal of the American Chemical Society, 2008, vol. 130, # 13, p. 4541 - 4552
  [2] Dyes and Pigments, 2014, vol. 107, p. 174 - 181
  [3] Patent: WO2015/121785, 2015, A1. Location in patent: Page/Page column 32; 33
  [4] Helvetica Chimica Acta, 1999, vol. 82, # 7, p. 981 - 1004
  [5] Chemical Communications, 2012, vol. 48, # 5, p. 750 - 752

2-Bromo-7-hydroxynaphthalene Upstream-Materialien And Downstream Produkte

2-Bromo-7-hydroxynaphthalene Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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