7-Methoxy-2-naphthol Struktur

7-Methoxy-2-naphthol

Bezeichnung:7-Methoxy-2-naphthol

CAS-Nr5060-82-2

Englisch Name:7-Methoxy-2-naphthol

CBNumberCB7700547

SummenformelC11H10O2

Molgewicht174.2

MOL-Datei5060-82-2.mol

7-Methoxy-2-naphthol physikalisch-chemischer Eigenschaften

Schmelzpunkt	116-119 °C(lit.)
Siedepunkt	336.7±15.0 °C(Predicted)
Dichte	1.193
storage temp.	Sealed in dry,Room Temperature
pka	9.45±0.40(Predicted)
Aggregatzustand	Crystalline Powder or Chunks
Farbe	White to brown
BRN	2207279
InChI	1S/C11H10O2/c1-13-11-5-3-8-2-4-10(12)6-9(8)7-11/h2-7,12H,1H3
InChIKey	UNFNRIIETORURP-UHFFFAOYSA-N
SMILES	COc1ccc2ccc(O)cc2c1

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
F	8-9-23
HS Code	29071990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

7-Methoxy-2-naphthol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White to brown solid
Verwenden
7-Methoxy-2-naphthol may be used in the synthesis of new 1H-benzo[f]chromene derivatives. It may be used in the synthesis of 7-methoxy-2-naphthyl (MN)-derived xylosides in which the methoxy group served as a marker for NMR characterization and UV detection.
Allgemeine Beschreibung
7-Methoxy-2-naphthol is a 7-substituted-2-naphthol. Crystal structure of 7-methoxy-2-naphthol has been reported. Reaction of 7-methoxy-2-naphthol with N-methyl-N-phenylhydrazine under thermal conditions has been reported.
Synthese

582-17-2

77-78-1

5060-82-2

General method: a mixture of 2,7-dihydroxynaphthalene (500 mg, 2.64 mmol), dimethyl sulfate (0.5 ml, 5.3 mmol) and potassium carbonate (73.1 mg, 5.3 mmol) in acetonitrile (10 ml) was refluxed for 1 hour. After completion of the reaction, the solvent was removed by evaporation and the residue was poured into water and extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate and subsequently concentrated under vacuum. The crude product was purified by silica gel column chromatography to afford 7-methoxy-2-naphthol using hexane/ethyl acetate (15:1) as eluent.
Einzelnachweise
[1] Molecular Pharmacology, 2013, vol. 84, # 5, p. 726 - 735
[2] Patent: US2006/52378, 2006, A1. Location in patent: Page/Page column 112
[3] Journal fuer Praktische Chemie (Leipzig), 1916, vol. <2> 94, p. 25
[4] Journal of medicinal chemistry, 1971, vol. 14, # 11, p. 1023 - 1026

7-Methoxy-2-naphthol Upstream-Materialien And Downstream Produkte

7-Methoxy-2-naphthol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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